Cerebrospinal fluid levels of IL-6 are decreased and correlate with cognitive status in DLB patients.

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Abstract

Inflammatory processes have previously been shown to influence cognition and progression of dementia. An involvement of interleukin (IL)-6 has in particular been suggested as altered levels of IL-6 in cerebrospinal fluid (CSF) have been found in patients with Alzheimer's disease (AD). Also, an association between cognitive decline and levels of IL-6 in CSF have been reported. The aim of the present study was to investigate whether patients clinically diagnosed with dementia with Lewy bodies (DLB) display altered CSF IL-6 levels in comparison with patients with AD and control subjects without dementia and whether the IL-6 levels are correlated with cognitive status and biomarkers for AD and synucleinopathy.

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  • Neurology
Original languageEnglish
Article number63
JournalAlzheimer's Research & Therapy
Volume7
Issue number1
Publication statusPublished - 2015
Publication categoryResearch
Peer-reviewedYes

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