Cerebrospinal fluid levels of the synaptic protein neurogranin correlates with cognitive decline in prodromal Alzheimer's disease.

Research output: Contribution to journalArticle

Abstract

Synaptic dysfunction is an early event in Alzheimer's disease (AD) pathogenesis and directly related to cognitive impairment. Consequently, synaptic biomarkers may be valuable tools for both early diagnosis and disease stage. Neurogranin (Ng) is a postsynaptic protein involved in memory consolidation.

Details

Authors
  • Hlin Kvartsberg
  • Flora H Duits
  • Martin Ingelsson
  • Niels Andreasen
  • Annika Öhrfelt
  • Kerstin Andersson
  • Gunnar Brinkmalm
  • Lars Lannfelt
  • Lennart Minthon
  • Oskar Hansson
  • Ulf Andreasson
  • Charlotte E Teunissen
  • Philip Scheltens
  • Wiesje M Van der Flier
  • Henrik Zetterberg
  • Erik Portelius
  • Kaj Blennow
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurology
Original languageEnglish
Pages (from-to)1180-1190
JournalAlzheimer's & Dementia
Volume11
Issue number10
Publication statusPublished - 2015
Publication categoryResearch
Peer-reviewedYes