Cerebrospinal fluid tau and Abeta42 as predictors of development of Alzheimer's disease in patients with mild cognitive impairment

Research output: Contribution to journalArticle

Abstract

We studied CSF-tau and CSF-Abeta42 in 16 patients with mild cognitive impairment (MCI) who at follow-up investigations 6-27 months later had progressed to Alzheimer's disease (AD) with dementia. For comparison, we studied 15 age-matched healthy individuals. At baseline, 14/16 (88%) of MCI patients had high CSF-tau and/or low CSF-Abeta42 levels. These findings show that these CSF-markers are abnormal before the onset of clinical dementia and that they may help to identify MCI patients that will develop AD. This is especially important when drugs with potential effects on the progression of AD will reach the clinical phase.

Details

Authors
  • N Andreasen
  • Lennart Minthon
  • E Vanmechelen
  • H Vanderstichele
  • P Davidsson
  • B Winblad
  • K Blennow
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurosciences
Original languageEnglish
Pages (from-to)5-8
JournalNeuroscience Letters
Volume273
Issue number1
Publication statusPublished - 1999
Publication categoryResearch
Peer-reviewedYes