Changes in aortic wall stiffness in men with alpha 1-antitrypsin deficiency

Research output: Contribution to journalArticle



To examine the diameter and distensibility of the abdominal aorta in patients with severe α1-antitrypsin deficiency, and to compare the results with those of normal subjects.
Material and methods:

Abdominal aortic diameter and stiffness (β) was measured using echo-tracking sonography in 19 men (mean age 50, range 25–79) and 17 women (mean age 46, range 26–62) with severe α2-antitrypsin deficiency. The results were compared with those of healthy individuals of corresponding age and gender.

There was no significant difference in the abdominal aortic diameter between controls and patients with α1-antitrypsin deficiency when corrected for age, sex and body surface area (men p = 0.20, women p = 0.10). Men with α1-antitrypsin deficiency showed significantly lower stiffness in the abdominal aorta compared to controls (p = 0.025), whereas women did not (p = 0.17).

No significant difference in abdominal aortic diameter could be detected in patients with α1-antitrypsin deficiency compared with controls. However, aortic distensibility in men with α1-antitrypsin deficiency is altered. This may reflect early vessel wall abnormality.


Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Surgery


  • Ultrasound, Abdominal aortic aneurysms, α1-antitrypsin deficiency, Distensibility
Original languageEnglish
Pages (from-to)252-257
JournalEuropean Journal of Vascular and Endovascular Surgery
Issue number4
Publication statusPublished - 1997
Publication categoryResearch

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200), Respiratory Medicine and Allergology (013230111), Clinical Physiology and Nuclear Medicine Unit (013242320)