Changes in aortic wall stiffness in men with alpha 1-antitrypsin deficiency

Research output: Contribution to journalArticle

Abstract

Objectives:

To examine the diameter and distensibility of the abdominal aorta in patients with severe α1-antitrypsin deficiency, and to compare the results with those of normal subjects.
Material and methods:

Abdominal aortic diameter and stiffness (β) was measured using echo-tracking sonography in 19 men (mean age 50, range 25–79) and 17 women (mean age 46, range 26–62) with severe α2-antitrypsin deficiency. The results were compared with those of healthy individuals of corresponding age and gender.
Results:

There was no significant difference in the abdominal aortic diameter between controls and patients with α1-antitrypsin deficiency when corrected for age, sex and body surface area (men p = 0.20, women p = 0.10). Men with α1-antitrypsin deficiency showed significantly lower stiffness in the abdominal aorta compared to controls (p = 0.025), whereas women did not (p = 0.17).
Conclusions:

No significant difference in abdominal aortic diameter could be detected in patients with α1-antitrypsin deficiency compared with controls. However, aortic distensibility in men with α1-antitrypsin deficiency is altered. This may reflect early vessel wall abnormality.

Details

Authors
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Surgery

Keywords

  • Ultrasound, Abdominal aortic aneurysms, α1-antitrypsin deficiency, Distensibility
Original languageEnglish
Pages (from-to)252-257
JournalEuropean Journal of Vascular and Endovascular Surgery
Volume14
Issue number4
Publication statusPublished - 1997
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200), Respiratory Medicine and Allergology (013230111), Clinical Physiology and Nuclear Medicine Unit (013242320)