Changes in GABA(B) receptor immunoreactivity after recurrent seizures in rats

Research output: Contribution to journalArticle

Abstract

GABA(B) receptors play an important role in the excitability of neuronal networks and can influence seizure activity. Here we demonstrate for the first time that kindling, an animal model for human temporal lobe epilepsy, leads to both early and delayed changes of GABA(B) receptor immunoreactivity in hippocampal and cortical areas. We propose that the altered GABA(B) receptor levels might be a compensatory mechanism to reduce excitability induced by recurrent kindled seizures, or alternatively, may promote the development of kindled epilepsy.

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Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurosciences

Keywords

  • GABAB, GABA, Kindling, Immunoreactivity, Epilepsy, Rat
Original languageEnglish
Pages (from-to)85-88
JournalNeuroscience Letters
Volume315
Issue number1-2
Publication statusPublished - 2001
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Restorative Neurology (0131000160), Neurology, Lund (013027000)