Changes in the pattern of paracetamol use in the periconception period in a Danish cohort

Research output: Contribution to journalArticle


Paracetamol is the most commonly used over-the-counter drug in pregnancy. It is generally considered to be safe, but prolonged antenatal exposure has been associated with offspring short- and long-term morbidity. Our aim was to describe the pattern of paracetamol use with a focus on frequent ingestion (more than once a week), 3months before and in early pregnancy. In this cohort, 8650 pregnant women responded to a web-based clinical questionnaire that included questions about drug use. Paracetamol was the most used drug before and in early pregnancy (35.2% and 6.5% of respondents, respectively). The proportion of frequent users decreased from 3.9% before to 0.9% in early pregnancy. Frequent paracetamol use was associated with smoking, co-morbidities, body mass index 25kg/m(2), unplanned pregnancy, no education and inability to understand Danish. A significant decrease in the proportion of women with any paracetamol use in early pregnancy was noted after access to large packs was restricted by legislation.


  • Anne S. Ersboll
  • Mette Hedegaard
  • Peter Damm
  • Marianne Johansen
  • Ann Tabor
  • Hanne Kristine Hegaard
External organisations
  • University of Copenhagen
  • Copenhagen University Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Obstetrics, Gynecology and Reproductive Medicine


  • Paracetamol, acetaminophen, pregnancy, antenatal care, prenatal care, exposure
Original languageEnglish
Pages (from-to)898-903
JournalActa Obstetricia et Gynecologica Scandinavica
Issue number8
Publication statusPublished - 2015
Publication categoryResearch

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