Characterization and modeling of acousto-optic signal strengths in highly scattering media

Research output: Contribution to journalArticle

Abstract

Ultrasound optical tomography (UOT) is an imaging technique based on the acousto-optic effect that can perform optical imaging with ultrasound resolution inside turbid media, and is thus interesting for biomedical applications, e.g. for assessing tissue blood oxygenation. In this paper, we present near background free measurements of UOT signal strengths using slow light filter signal detection. We carefully analyze each part of our experimental setup and match measured signal strengths with calculations based on diffusion theory. This agreement between experiment and theory allows us to assert the deep tissue imaging potential of ∼ 5 cm for UOT of real human tissues predicted by previous theoretical studies [Biomed. Opt. Express 8, 4523 (2017)] with greater confidence, and indicate that future theoretical analysis of optimized UOT systems can be expected to be reliable.

Details

Authors
Organisations
External organisations
  • SpectraCure AB
  • Lund University
  • Chalmers University of Technology
  • Tyndall National Institute
  • University College Cork
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Physical Sciences
  • Medical Laboratory and Measurements Technologies
Original languageEnglish
Pages (from-to)5565-5584
Number of pages20
JournalBiomedical Optics Express
Volume10
Issue number11
Publication statusPublished - 2019
Publication categoryResearch
Peer-reviewedYes