Characterization and modeling of acousto-optic signal strengths in highly scattering media

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Characterization and modeling of acousto-optic signal strengths in highly scattering media. / Bengtsson, Alexander; Hill, David; Li, Meng; Di, Mengqiao; Cinthio, Magnus; Erlöv, Tobias; Andersson-Engels, Stefan; Reistad, Nina; Walther, Andreas; Rippe, Lars; Kröll, Stefan.

In: Biomedical Optics Express, Vol. 10, No. 11, 2019, p. 5565-5584.

Research output: Contribution to journalArticle

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TY - JOUR

T1 - Characterization and modeling of acousto-optic signal strengths in highly scattering media

AU - Bengtsson, Alexander

AU - Hill, David

AU - Li, Meng

AU - Di, Mengqiao

AU - Cinthio, Magnus

AU - Erlöv, Tobias

AU - Andersson-Engels, Stefan

AU - Reistad, Nina

AU - Walther, Andreas

AU - Rippe, Lars

AU - Kröll, Stefan

PY - 2019

Y1 - 2019

N2 - Ultrasound optical tomography (UOT) is an imaging technique based on the acousto-optic effect that can perform optical imaging with ultrasound resolution inside turbid media, and is thus interesting for biomedical applications, e.g. for assessing tissue blood oxygenation. In this paper, we present near background free measurements of UOT signal strengths using slow light filter signal detection. We carefully analyze each part of our experimental setup and match measured signal strengths with calculations based on diffusion theory. This agreement between experiment and theory allows us to assert the deep tissue imaging potential of ∼ 5 cm for UOT of real human tissues predicted by previous theoretical studies [Biomed. Opt. Express 8, 4523 (2017)] with greater confidence, and indicate that future theoretical analysis of optimized UOT systems can be expected to be reliable.

AB - Ultrasound optical tomography (UOT) is an imaging technique based on the acousto-optic effect that can perform optical imaging with ultrasound resolution inside turbid media, and is thus interesting for biomedical applications, e.g. for assessing tissue blood oxygenation. In this paper, we present near background free measurements of UOT signal strengths using slow light filter signal detection. We carefully analyze each part of our experimental setup and match measured signal strengths with calculations based on diffusion theory. This agreement between experiment and theory allows us to assert the deep tissue imaging potential of ∼ 5 cm for UOT of real human tissues predicted by previous theoretical studies [Biomed. Opt. Express 8, 4523 (2017)] with greater confidence, and indicate that future theoretical analysis of optimized UOT systems can be expected to be reliable.

U2 - 10.1364/BOE.10.005565

DO - 10.1364/BOE.10.005565

M3 - Article

C2 - 31799031

AN - SCOPUS:85078119267

VL - 10

SP - 5565

EP - 5584

JO - Biomedical Optics Express

JF - Biomedical Optics Express

SN - 2156-7085

IS - 11

ER -