Characterization of heme binding to recombinant α1-microglobulin.

Research output: Contribution to journalArticle

Abstract

Alpha-1-microglobulin (A1M), a small lipocalin protein found in plasma and tissues, has been identified as a heme and radical scavenger that may participate in the mitigation of toxicities caused by degradation of hemoglobin. The objective of this work was to investigate heme interactions with A1M in vitro using various analytical techniques and to optimize analytical methodology suitable for rapid evaluation of the ligand binding properties of recombinant A1M versions.

Details

Authors
  • Elena Karnaukhova
  • Sigurbjörg Rutardottir
  • Mohsen Rajabi
  • Lena Wester Rosenlöf
  • Abdu I Alayash
  • Bo Åkerström
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Infectious Medicine
Original languageEnglish
Article number465
JournalFrontiers in Physiology
Volume5
Publication statusPublished - 2014
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Division of Infection Medicine (BMC) (013024020), Medical Inflammation Research (013212019)

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