Chemerin Is an Antimicrobial Agent in Human Epidermis

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Abstract

Chemerin, a chemoattractant ligand for chemokine-like receptor 1 (CMKLR1) is predicted to share similar tertiary structure with antibacterial cathelicidins. Recombinant chemerin has antimicrobial activity. Here we show that endogenous chemerin is abundant in human epidermis, and that inhibition of bacteria growth by exudates from organ cultures of primary human skin keratinocytes is largely chemerin-dependent. Using a panel of overlapping chemerin-derived synthetic peptides, we demonstrate that the antibacterial activity of chemerin is primarily mediated by Val 66 -Pro 85, which causes direct bacterial lysis. Therefore, chemerin is an antimicrobial agent in human skin.

Details

Authors
  • Magdalena Banas
  • Katarzyna Zabieglo
  • Gopinath Kasetty
  • Monika Kapinska-Mrowiecka
  • Julia Borowczyk
  • Justyna Drukala
  • Krzysztof Murzyn
  • Brian A. Zabel
  • Eugene C. Butcher
  • Jens M. Schroeder
  • Artur Schmidtchen
  • Joanna Cichy
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Dermatology and Venereal Diseases
Original languageEnglish
Article numbere58709
JournalPLoS ONE
Volume8
Issue number3
Publication statusPublished - 2013
Publication categoryResearch
Peer-reviewedYes

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