Chemokine receptor expression defines heterogeneity in the earliest thymic migrants

Research output: Contribution to journalArticle

Abstract

Chemokine signaling has been implicated in directing colonization of the fetal thymus by hematopoietic precursors. However, the patterns of expression of the chemokine receptors responsible for directing thymic colonization by the earliest thymic migrants remain unknown. We have identified heterogeneity within the earliest thymus seeding cells based on chemokine receptor expression. By analyzing the first wave of progenitors to colonize the thymus at E12 of gestation, we show that multiple chemokine receptors are expressed by T-lymphoid precursors present within perithymic mesenchyme, while expression of chemokine ligands is limited to CCL21, CCL25 and CXCL12, which are located in distinct epithelial and mesenchymal compartments of the thymic/parathyroid anlagen. Collectively, these results identify multiple populations of T-lymphoid precursors colonizing the fetal thymus and provide evidence for several potential pathways mediating migration of precursors into the embryonic thymus.

Details

Authors
  • William E. Jenkinson
  • Simona W. Rossi
  • Sonia Parnell
  • William Agace
  • Yousuke Takahama
  • Eric J. Jenkinson
  • Graham Anderson
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Immunology in the medical area

Keywords

  • chemokine receptor, colonization, T cell, thymus
Original languageEnglish
Pages (from-to)2090-2096
JournalEuropean Journal of Immunology
Volume37
Issue number8
Publication statusPublished - 2007
Publication categoryResearch
Peer-reviewedYes