Chloroplast thylakoids reduce glucose uptake and decrease intestinal macromolecular permeability.

Research output: Contribution to journalArticle


Thylakoid membranes, derived from chloroplasts, have previously been shown to retard fat digestion and lower blood glucose levels after oral intake. The purpose of the present study was to investigate the effect of thylakoid membranes on the passage of methyl-glucose, dextran and ovalbumin over rat intestine in vitro using Ussing chambers. The results show that thylakoids retard the passage of each of the test molecules in a dose-dependent way. The thylakoids appear to be attached on the mucosal surface and a mechanism is suggested that the thylakoids delay the passage of the test molecules by sterical hindrance. The present results indicate that thylakoid membranes may be useful both to control intestinal absorption of glucose and to enhance the barrier function of the intestine.


Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Nutrition and Dietetics


  • 3-O-Methylglucose, Animals, Area Under Curve, Chloroplasts, Dextrans, Dose-Response Relationship, Drug, Glucose, Intestines, Macromolecular Substances, Mice, Ovalbumin, Permeability, Rats, Rats, Sprague-Dawley, Spinacia oleracea, Thylakoids, Time Factors
Original languageEnglish
Pages (from-to)836-844
Number of pages9
JournalBritish Journal of Nutrition
Issue number6
Publication statusPublished - 2011
Publication categoryResearch

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