Chromatin, epigenetics and stem cells

Research output: Contribution to journalArticle

Abstract

Epigenetics is a term that has changed its meaning with the increasing biological knowledge on developmental processes. However, its current application to stem cell biology is often imprecise and is conceptually problematic. This article addresses two different subjects, the definition of epigenetics and chromatin states of stem and differentiated cells. We describe mechanisms that regulate chromatin changes and provide an overview of chromatin states of stem and differentiated cells. Moreover, a modification of the current epigenetics definition is proposed that is not restricted by the heritability of gene expression throughout cell divisions and excludes translational gene expression control.

Details

Authors
  • Tim C Roloff
  • Ulrike Nuber
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cell and Molecular Biology

Keywords

  • Stem cells, Epigenetics, Chromatin, Histone modification, DNA methylation, Gene expression
Original languageEnglish
Pages (from-to)123-135
JournalEuropean Journal of Cell Biology
Volume84
Issue number2-3
Publication statusPublished - 2005
Publication categoryResearch
Peer-reviewedYes