Chromosome aberrations in psoriatic patients treated with arsenic

Research output: Contribution to journalArticle

Abstract

A significantly increased frequency of chromosomal aberrations was found in lymphocytes from eight psoriatic patients previously treated with arsenic than in lymphocytes from eight psoriatics with no such previous treatment. In most patients the arsenic therapy was discontinued more than 15 years ago. In the arsenic-treated group a statistically significant heterogeneity was found with respect to the frequency of aberrations. The frequency of sister chromatid exchange was not increased in the arsenic-treated patients.

Details

Authors
  • I Nordenson
  • S Salmonsson
  • E Brun
  • G Beckman
External organisations
  • Umeå University
Research areas and keywords

Keywords

  • Adult, Aged, Arsenic/adverse effects, Chromatids/drug effects, Chromosome Aberrations, Crossing Over, Genetic/drug effects, Female, Humans, Lymphocytes/ultrastructure, Male, Middle Aged, Psoriasis/drug therapy, Time Factors
Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalHuman Genetics
Volume48
Issue number1
Publication statusPublished - 1979 Apr 17
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes