Chronic Arthritis in Rats; Pathogenesis and genetic factors

Research output: ThesisDoctoral Thesis (compilation)

Abstract

The immune pathology and MHC association of chronic arthritis was studied in three rat models for reumatoid arthritis (RA). Susceptible rat strains develop a T cell dependent chronic disease after immunization with rat collagen type II (CII). The LEW rat does not develop arthritis after immunization with rat CII, but a heterologous immune response to pepsin can break the tolerance to CII and render it susceptible to collagen induced arthritis (CIA). DA rats are protected against CIA if pre-treated with denatured CII or native CII in a non arthritogenic fashion. This was associated with a poor B cell response but a normal T cell response compared to that of CIA, suggesting that B cells specific for conformational epitopes on the CII molecule are essential for the development of chronic CIA.

The non-immunogenic adjuvants, avridine and pristane induced chronic T cell dependent arthritis in rats. CIA, AvIA and PIA had a similar MHC association, with RT1a and RT1f being the most susceptible haplotypes. In AvIA and PIA, the MHC mainly influenced the chronicity of arthritis. The genetic control of the PIA model, apart from the MHC association (pia1), was further analyzed in a cross between E3 and DA. A total genome scan of the F2 progeny revealed an additional loci; pia2 on chromosome 12 and two suggestive loci pia3 on chromosome 6 and pia4 on chromosome 11. Pia2 and pia4 were also associated with an a1-acid glycoprotein production and an IgG2b and rheumatoid factor response, whereas pia3 was associated with a fibronectin and IL-6 response.

Details

Authors
  • Carina Vingsbo Lundberg
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Immunology in the medical area

Keywords

  • rheumatology locomotion, muscle system, Skeleton, autoimmunity/inflammation/adjuvans/MHC association, Skelett, muskelsystem, reumatologi
Original languageEnglish
QualificationDoctor
Awarding Institution
Supervisors/Assistant supervisor
  • [unknown], [unknown], Supervisor, External person
Award date1997 Nov 8
Publisher
  • Center for Molecular Biomedicine, Lund University
Print ISBNs91-628-2715-4
Publication statusPublished - 1997
Publication categoryResearch

Bibliographic note

Defence details Date: 1997-11-08 Time: 10:15 Place: Hörsal A, Kemicentum, Lund External reviewer(s) Name: Emmrich, Frank Title: [unknown] Affiliation: [unknown] --- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Medical Inflammation Research (013212019)