Chronic cobalt exposure affects antioxidants and ATP production in rat myocardium

Research output: Contribution to journalArticle


Chronic cobalt exposure is characterized by severe cardiac insufficiency. Since the mechanisms of cobalt toxicity are not yet clear, we analysed the effects of chronic cobalt exposure on antioxidant enzyme activities and myocardial mitochondrial ATP production rate in a rat model. One group of rats was fed a conventional diet and another a cobalt supplemented diet for 24 weeks. The manganese-superoxide dismutase activity was markedly reduced in the cobalt rats (18±4.7 U/mg protein) compared to the control rats (100±22 U/mg protein; p


  • N. Clyne
  • C. Hofman-Bang
  • Y. Haga
  • N. Hatori
  • S. L. Marklund
  • S. K. Pehrsson
  • R. Wibom
External organisations
  • Karolinska University Hospital
  • Norrland University Hospital
Research areas and keywords


  • ATP production rate, Chronic cobalt toxicity, Manganese-superoxide dismutase, Rat myocardium, Superoxide radicals
Original languageEnglish
Pages (from-to)609-614
Number of pages6
JournalScandinavian Journal of Clinical & Laboratory Investigation
Issue number8
Publication statusPublished - 2001
Publication categoryResearch
Externally publishedYes