Chronic pancreatitis: potential future interventions.

Research output: Contribution to journalReview article

Abstract

Chronic pancreatitis is a common disorder of which the underlying pathogenic mechanisms still are incompletely understood. In the last decade, increasing evidence has shown that activated pancreatic stellate cells play a key role in the fibrosis development associated with chronic pancreatitis as well as pancreatic cancer. During pancreatic injury or inflammation, quiescent stellate cells undergo a phenotypic transformation, characterized by smooth muscle alpha-actin expression and increased synthesis of extracellular matrix proteins. Hitherto, specific therapies to prevent or reverse pancreatic fibrosis are unavailable. This review addresses current insights into pathological mechanisms underlying chronic pancreatitis and their applicability as concerns the development of potential future therapeutic approaches.

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Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Gastroenterology and Hepatology

Keywords

  • * Chronic: physiopathology * Chronic: therapy * Pancreatitis
Original languageEnglish
Pages (from-to)1022-1028
JournalScandinavian Journal of Gastroenterology
Volume45
Issue number9
Publication statusPublished - 2010
Publication categoryResearch
Peer-reviewedYes