Chronic widespread pain is associated with slower cognitive processing speed in middle-aged and older European men

Research output: Contribution to journalArticle


Evidence from clinic-based studies suggests that the fibromyalgia syndrome (FMS) is associated with impairment in cognitive function though the mechanism is unclear. The aim of this analysis was to determine whether there is a similar association between chronic widespread pain (CWP), a cardinal feature of FMS, and impaired cognition in a community setting. Men (n = 3369, 40-79 years) were recruited from population registers in eight centres for participation in the European Male Ageing Study (EMAS). Subjects completed a pain questionnaire and pain manikin, with the presence of CWP defined using the American College of Rheumatology criteria. The cognitive functions measured were: visuospatial-constructional ability and visual memory (Rey-Osterrieth Complex Figure [ROCF]); visual recognition (Camden Topographical Recognition Memory test [CTRM]); and psychomotor processing speed (Digit-Symbol Substitution test [DSST]). We restricted our analysis to those subjects reporting pain that satisfied the criteria for CWP and those who were pain free. Of these 1539 men [mean (SD) age 60 (11) years], 266 had CWP. All cognitive test scores declined cross-sectionally with age (P < 0.05). In age-adjusted linear regressions men with CWP had a lower DSST score (beta = -2.4, P < 0.001) compared to pain free subjects. After adjustment for lifestyle and health factors the association between pain status and the DSST score was attenuated but remained significant (beta = -1.02, P = 0.04). There was no association between CWP and the ROCF-copy, ROCF-recall or CTRM scores. CWP is associated with slower psychomotor processing speed among community-dwelling European men. Prospective studies are required to confirm this observation and explore possible mechanisms for the association. (C) 2010 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.


  • D. M. Lee
  • N. Pendleton
  • A. Tajar
  • T. W. O'Neill
  • D. B. O'Connor
  • G. Bartfai
  • S. Boonen
  • F. F. Casanueva
  • J. D. Finn
  • G. Forti
  • T. S. Han
  • I. T. Huhtaniemi
  • K. Kula
  • M. E. J. Lean
  • M. Punab
  • A. J. Silman
  • D. Vanderschueren
  • C. M. Moseley
  • F. C. W. Wu
  • J. McBeth
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Obstetrics, Gynecology and Reproductive Medicine


  • Population survey, Male health, Ageing, Chronic pain, Cognition, Epidemiology
Original languageEnglish
Pages (from-to)30-36
Issue number1
Publication statusPublished - 2010
Publication categoryResearch