Circulating Fibroblast Growth Factor-23 Is Associated With Fat Mass and Dyslipidemia in Two Independent Cohorts of Elderly Individuals

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Circulating Fibroblast Growth Factor-23 Is Associated With Fat Mass and Dyslipidemia in Two Independent Cohorts of Elderly Individuals. / Mirza, Majd A. I.; Alsio, Johan; Hammarstedt, Ann; Erben, Reinhold G.; Michaelsson, Karl; Tivesten, Asa; Marsell, Richard; Orwoll, Eric; Karlsson, Magnus; Ljunggren, Osten; Mellstrom, Dan; Lind, Lars; Ohlsson, Claes; Larsson, Tobias E.

In: Arteriosclerosis, Thrombosis and Vascular Biology, Vol. 31, No. 1, 2011, p. 219.

Research output: Contribution to journalArticle

Harvard

Mirza, MAI, Alsio, J, Hammarstedt, A, Erben, RG, Michaelsson, K, Tivesten, A, Marsell, R, Orwoll, E, Karlsson, M, Ljunggren, O, Mellstrom, D, Lind, L, Ohlsson, C & Larsson, TE 2011, 'Circulating Fibroblast Growth Factor-23 Is Associated With Fat Mass and Dyslipidemia in Two Independent Cohorts of Elderly Individuals', Arteriosclerosis, Thrombosis and Vascular Biology, vol. 31, no. 1, pp. 219. https://doi.org/10.1161/ATVBAHA.110.214619

APA

Mirza, M. A. I., Alsio, J., Hammarstedt, A., Erben, R. G., Michaelsson, K., Tivesten, A., Marsell, R., Orwoll, E., Karlsson, M., Ljunggren, O., Mellstrom, D., Lind, L., Ohlsson, C., & Larsson, T. E. (2011). Circulating Fibroblast Growth Factor-23 Is Associated With Fat Mass and Dyslipidemia in Two Independent Cohorts of Elderly Individuals. Arteriosclerosis, Thrombosis and Vascular Biology, 31(1), 219. https://doi.org/10.1161/ATVBAHA.110.214619

CBE

Mirza MAI, Alsio J, Hammarstedt A, Erben RG, Michaelsson K, Tivesten A, Marsell R, Orwoll E, Karlsson M, Ljunggren O, Mellstrom D, Lind L, Ohlsson C, Larsson TE. 2011. Circulating Fibroblast Growth Factor-23 Is Associated With Fat Mass and Dyslipidemia in Two Independent Cohorts of Elderly Individuals. Arteriosclerosis, Thrombosis and Vascular Biology. 31(1):219. https://doi.org/10.1161/ATVBAHA.110.214619

MLA

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Author

Mirza, Majd A. I. ; Alsio, Johan ; Hammarstedt, Ann ; Erben, Reinhold G. ; Michaelsson, Karl ; Tivesten, Asa ; Marsell, Richard ; Orwoll, Eric ; Karlsson, Magnus ; Ljunggren, Osten ; Mellstrom, Dan ; Lind, Lars ; Ohlsson, Claes ; Larsson, Tobias E. / Circulating Fibroblast Growth Factor-23 Is Associated With Fat Mass and Dyslipidemia in Two Independent Cohorts of Elderly Individuals. In: Arteriosclerosis, Thrombosis and Vascular Biology. 2011 ; Vol. 31, No. 1. pp. 219.

RIS

TY - JOUR

T1 - Circulating Fibroblast Growth Factor-23 Is Associated With Fat Mass and Dyslipidemia in Two Independent Cohorts of Elderly Individuals

AU - Mirza, Majd A. I.

AU - Alsio, Johan

AU - Hammarstedt, Ann

AU - Erben, Reinhold G.

AU - Michaelsson, Karl

AU - Tivesten, Asa

AU - Marsell, Richard

AU - Orwoll, Eric

AU - Karlsson, Magnus

AU - Ljunggren, Osten

AU - Mellstrom, Dan

AU - Lind, Lars

AU - Ohlsson, Claes

AU - Larsson, Tobias E.

PY - 2011

Y1 - 2011

N2 - Objective-Disturbances in mineral metabolism define an increased cardiovascular risk in patients with chronic kidney disease. Fibroblast growth factor-23 (FGF23) is a circulating regulator of phosphate and vitamin D metabolism and has recently been implicated as a putative pathogenic factor in cardiovascular disease. Because other members of the FGF family play a role in lipid and glucose metabolism, we hypothesized that FGF23 would associate with metabolic factors that predispose to an increased cardiovascular risk. The goal of this study was to investigate the relationship between FGF23 and metabolic cardiovascular risk factors in the community. Methods and Results-Relationships between serum FGF23 and body mass index (BMI), waist circumference, waist-to-hip ratio, serum lipids, and fat mass were examined in 2 community-based, cross-sectional cohorts of elderly whites (Osteoporotic Fractures in Men Study: 964 men aged 75 +/- 3.2; Prospective Investigation of the Vasculature in Uppsala Seniors study: 946 men and women aged 70). In both cohorts, FGF23 associated negatively with high-density lipoprotein and apolipoprotein A1 (7% to 21% decrease per 1-SD increase in log FGF23; P < 0.01) and positively with triglycerides (11% to 14% per 1-SD increase in log FGF23; P < 0.01). A 1-SD increase in log FGF23 was associated with a 7% to 20% increase in BMI, waist circumference, and waist-to-hip ratio and a 7% to 18% increase in trunk and total body fat mass (P < 0.01) as determined by whole-body dual x-ray absorptiometry. FGF23 levels were higher in subjects with the metabolic syndrome compared with those without (46.4 versus 41.2 pg/ mL; P < 0.05) and associated with an increased risk of having the metabolic syndrome (OR per 1-SD increase in log FGF23, 1.21; 95% CI, 1.04 to 1.40; P < 0.05). Conclusion-We report for the first time on associations between circulating FGF23, fat mass, and adverse lipid metabolism resembling the metabolic syndrome, potentially representing a novel pathway(s) linking high FGF23 to an increased cardiovascular risk. (Arterioscler Thromb Vasc Biol. 2011;31:219-227.)

AB - Objective-Disturbances in mineral metabolism define an increased cardiovascular risk in patients with chronic kidney disease. Fibroblast growth factor-23 (FGF23) is a circulating regulator of phosphate and vitamin D metabolism and has recently been implicated as a putative pathogenic factor in cardiovascular disease. Because other members of the FGF family play a role in lipid and glucose metabolism, we hypothesized that FGF23 would associate with metabolic factors that predispose to an increased cardiovascular risk. The goal of this study was to investigate the relationship between FGF23 and metabolic cardiovascular risk factors in the community. Methods and Results-Relationships between serum FGF23 and body mass index (BMI), waist circumference, waist-to-hip ratio, serum lipids, and fat mass were examined in 2 community-based, cross-sectional cohorts of elderly whites (Osteoporotic Fractures in Men Study: 964 men aged 75 +/- 3.2; Prospective Investigation of the Vasculature in Uppsala Seniors study: 946 men and women aged 70). In both cohorts, FGF23 associated negatively with high-density lipoprotein and apolipoprotein A1 (7% to 21% decrease per 1-SD increase in log FGF23; P < 0.01) and positively with triglycerides (11% to 14% per 1-SD increase in log FGF23; P < 0.01). A 1-SD increase in log FGF23 was associated with a 7% to 20% increase in BMI, waist circumference, and waist-to-hip ratio and a 7% to 18% increase in trunk and total body fat mass (P < 0.01) as determined by whole-body dual x-ray absorptiometry. FGF23 levels were higher in subjects with the metabolic syndrome compared with those without (46.4 versus 41.2 pg/ mL; P < 0.05) and associated with an increased risk of having the metabolic syndrome (OR per 1-SD increase in log FGF23, 1.21; 95% CI, 1.04 to 1.40; P < 0.05). Conclusion-We report for the first time on associations between circulating FGF23, fat mass, and adverse lipid metabolism resembling the metabolic syndrome, potentially representing a novel pathway(s) linking high FGF23 to an increased cardiovascular risk. (Arterioscler Thromb Vasc Biol. 2011;31:219-227.)

KW - metabolism

KW - lipids

KW - growth factors

KW - epidemiology

KW - elderly

KW - cardiovascular disease prevention

KW - diabetes mellitus

KW - FGF-23

KW - FGF23

KW - Fibroblast growth factor-23

U2 - 10.1161/ATVBAHA.110.214619

DO - 10.1161/ATVBAHA.110.214619

M3 - Article

C2 - 20966399

VL - 31

SP - 219

JO - Arteriosclerosis, Thrombosis and Vascular Biology

JF - Arteriosclerosis, Thrombosis and Vascular Biology

SN - 1524-4636

IS - 1

ER -