Clinical and Microbiological Characteristics of Severe Streptococcus pyogenes Disease in Europe.

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Clinical and Microbiological Characteristics of Severe Streptococcus pyogenes Disease in Europe. / Luca, Bogdan; Darenberg, Jessica; Neal, Shona; Siljander, Tuula; Strakova, Lenka; Tanna, Asha; Creti, Roberta; Ekelund, Kim; Koliou, Maria; Tassios, Panayotis T; van der Linden, Mark; Straut, Monica; Vuopio-Varkila, Jaana; Bouvet, Anne; Efstratiou, Androulla; Schalén, Claës; Henriques-Normark, Birgitta; Jasir, Aftab.

In: Journal of Clinical Microbiology, Vol. 47, 2009, p. 1155-1165.

Research output: Contribution to journalArticle

Harvard

Luca, B, Darenberg, J, Neal, S, Siljander, T, Strakova, L, Tanna, A, Creti, R, Ekelund, K, Koliou, M, Tassios, PT, van der Linden, M, Straut, M, Vuopio-Varkila, J, Bouvet, A, Efstratiou, A, Schalén, C, Henriques-Normark, B & Jasir, A 2009, 'Clinical and Microbiological Characteristics of Severe Streptococcus pyogenes Disease in Europe.', Journal of Clinical Microbiology, vol. 47, pp. 1155-1165. https://doi.org/10.1128/JCM.02155-08

APA

Luca, B., Darenberg, J., Neal, S., Siljander, T., Strakova, L., Tanna, A., Creti, R., Ekelund, K., Koliou, M., Tassios, P. T., van der Linden, M., Straut, M., Vuopio-Varkila, J., Bouvet, A., Efstratiou, A., Schalén, C., Henriques-Normark, B., & Jasir, A. (2009). Clinical and Microbiological Characteristics of Severe Streptococcus pyogenes Disease in Europe. Journal of Clinical Microbiology, 47, 1155-1165. https://doi.org/10.1128/JCM.02155-08

CBE

Luca B, Darenberg J, Neal S, Siljander T, Strakova L, Tanna A, Creti R, Ekelund K, Koliou M, Tassios PT, van der Linden M, Straut M, Vuopio-Varkila J, Bouvet A, Efstratiou A, Schalén C, Henriques-Normark B, Jasir A. 2009. Clinical and Microbiological Characteristics of Severe Streptococcus pyogenes Disease in Europe. Journal of Clinical Microbiology. 47:1155-1165. https://doi.org/10.1128/JCM.02155-08

MLA

Vancouver

Author

Luca, Bogdan ; Darenberg, Jessica ; Neal, Shona ; Siljander, Tuula ; Strakova, Lenka ; Tanna, Asha ; Creti, Roberta ; Ekelund, Kim ; Koliou, Maria ; Tassios, Panayotis T ; van der Linden, Mark ; Straut, Monica ; Vuopio-Varkila, Jaana ; Bouvet, Anne ; Efstratiou, Androulla ; Schalén, Claës ; Henriques-Normark, Birgitta ; Jasir, Aftab. / Clinical and Microbiological Characteristics of Severe Streptococcus pyogenes Disease in Europe. In: Journal of Clinical Microbiology. 2009 ; Vol. 47. pp. 1155-1165.

RIS

TY - JOUR

T1 - Clinical and Microbiological Characteristics of Severe Streptococcus pyogenes Disease in Europe.

AU - Luca, Bogdan

AU - Darenberg, Jessica

AU - Neal, Shona

AU - Siljander, Tuula

AU - Strakova, Lenka

AU - Tanna, Asha

AU - Creti, Roberta

AU - Ekelund, Kim

AU - Koliou, Maria

AU - Tassios, Panayotis T

AU - van der Linden, Mark

AU - Straut, Monica

AU - Vuopio-Varkila, Jaana

AU - Bouvet, Anne

AU - Efstratiou, Androulla

AU - Schalén, Claës

AU - Henriques-Normark, Birgitta

AU - Jasir, Aftab

PY - 2009

Y1 - 2009

N2 - In an attempt to compare the epidemiology of severe S. pyogenes infection within Europe, prospective data were collected through the Strep-EURO programme. Surveillance of severe S. pyogenes infection diagnosed during 2003 and 2004 was undertaken in eleven countries across Europe using a standardised case definition and questionnaire. Patient data as well as bacterial isolates were collected and characterized by T- and, M/emm-typing and selected strains were analysed for presence of superantigen genes. Data were analysed to compare the clinical and microbiological patterns of infections across participating countries. Totally 4353 isolates were collected from 5521 cases with severe S. pyogenes infection identified. It was wide diversity of M/emm-types (104) found among the S. pyogenes clinical isolates but M/emm-type distribution varied broadly between participating countries. The ten most predominant M/emm-types were 1, 28, 3, 89, 87, 12, 4, 83, 81, and 5 in descending order. A correlation was found between some specific disease manifestation, age of patients and emm-types. Streptococcal toxic shock syndrome and necrotizing fasciitis, although caused by a large number of types, were particularly associated with M/emm-types 1 and 3. The emm-types included in the 26-valent vaccine under development, were generally well represented in the presentmaterial; 16 of the vaccine types accounted for 69% of isolates. The Strep-EURO collaborative programme has contributed to enhance the knowledge on the spread of invasive disease caused by S. pyogenes within Europe and encourage future surveillance with notification of cases and characterisation of strains, important for vaccine strategies and other health care issues.

AB - In an attempt to compare the epidemiology of severe S. pyogenes infection within Europe, prospective data were collected through the Strep-EURO programme. Surveillance of severe S. pyogenes infection diagnosed during 2003 and 2004 was undertaken in eleven countries across Europe using a standardised case definition and questionnaire. Patient data as well as bacterial isolates were collected and characterized by T- and, M/emm-typing and selected strains were analysed for presence of superantigen genes. Data were analysed to compare the clinical and microbiological patterns of infections across participating countries. Totally 4353 isolates were collected from 5521 cases with severe S. pyogenes infection identified. It was wide diversity of M/emm-types (104) found among the S. pyogenes clinical isolates but M/emm-type distribution varied broadly between participating countries. The ten most predominant M/emm-types were 1, 28, 3, 89, 87, 12, 4, 83, 81, and 5 in descending order. A correlation was found between some specific disease manifestation, age of patients and emm-types. Streptococcal toxic shock syndrome and necrotizing fasciitis, although caused by a large number of types, were particularly associated with M/emm-types 1 and 3. The emm-types included in the 26-valent vaccine under development, were generally well represented in the presentmaterial; 16 of the vaccine types accounted for 69% of isolates. The Strep-EURO collaborative programme has contributed to enhance the knowledge on the spread of invasive disease caused by S. pyogenes within Europe and encourage future surveillance with notification of cases and characterisation of strains, important for vaccine strategies and other health care issues.

U2 - 10.1128/JCM.02155-08

DO - 10.1128/JCM.02155-08

M3 - Article

C2 - 19158266

VL - 47

SP - 1155

EP - 1165

JO - Journal of Clinical Microbiology

JF - Journal of Clinical Microbiology

SN - 1098-660X

ER -