Clinical outcome and microvascular blood flow in VAC® and Sorbalgon® treated peri-vascular infected wounds in the groin after vascular surgery - an early interim analysis.

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Abstract

Vacuum-assisted wound closure (VAC®) therapy is considered to be superior to conventional dressings in the treatment of peri-vascular groin infections after vascular surgery at our department. Therefore, we wanted to perform an early interim analysis of clinical outcome in these seriously ill patients at risk for amputation and death. Patients were randomised to either VAC® (n = 5) or Sorbalgon® (n = 5; best other treatment) therapy after surgical debridement. Non-invasive laser Doppler perfusion imaging (LDPI) studies of the skin adjacent to the undressed wound were performed after 14 days of wound treatment. There were no difference in LDPI values in VAC® versus Sorbalgon® treated patients (P = 0·46). One patient in the VAC® group suffered from two re-bleeding episodes, leading to vascular resection and transfemoral amputation and in the Sorbalgon® group two had a complete wound healing time of more than 4 months and one had a visible interposition bypass graft in the groin after 1 month of treatment. No patient died due to the groin infection. Although not statistically proven, fewer wound treatment failures were recorded in the VAC® group, justifying this early interim analysis. LDPI studies were feasible.

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Subject classification (UKÄ) – MANDATORY

  • Cardiac and Cardiovascular Systems
  • Radiology, Nuclear Medicine and Medical Imaging
Original languageEnglish
Pages (from-to)377-382
JournalInternational Wound Journal
Volume10
Issue number4
Publication statusPublished - 2013
Publication categoryResearch
Peer-reviewedYes