Clinical progression in early and late stages of disease in a cohort of individuals infected with human immunodeficiency virus-2 in Guinea-Bissau

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@article{73b948a3025440a5b35ba38666c5d9db,
title = "Clinical progression in early and late stages of disease in a cohort of individuals infected with human immunodeficiency virus-2 in Guinea-Bissau",
abstract = "The aim of this study was to assess the rate of clinical progression to early and late stages of human immunodeficiency virus-2 (HIV-2) infection. CD4 cell counts and other potential prognostic markers for disease progression were also evaluated. In January 1990 an open prospective cohort of police officers in Guinea-Bissau was initiated with yearly serological and clinical follow-up. Follow-up ended in June 1998. Symptoms were classified according to the World Health Organization staging system. The analysis included 148 HIV-2-seropositive subjects and 177 HIV-seronegative controls. 25 of the HIV-2-positive individuals were seroconverters (seroincident cases). The progression rate to stage 3 of HIV-2-positive subjects in stage 1 + 2 was 8.6/100 person-years (py) ( rate ratio 6.2 compared with HIV-negative controls, 95{\%} confidence interval 2.7 - 14.2, p< 0.001), and the progression rate to stage 4, i.e. acquired immunodeficiency syndrome ( AIDS), was 2.1/100 py. HIV-2-positive people in stage 3 at inclusion progressed to AIDS at a rate of 16.9/100 py. CD4{\%} &LE; 20 was found to be a significant prognostic marker for progression to stage 4, both from stage 1 + 2 and from stage 3. The clinical progression in this cohort of HIV-2-infected subjects was generally lower than that in HIV-1-positive cohorts.",
author = "Hans Norrgren and {Da Silva}, Z and A Biague and S Andersson and G Biberfeld",
note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Division of Infection Medicine (SUS) (013008000)",
year = "2003",
doi = "10.1080/00365540310000210",
language = "English",
volume = "35",
pages = "265--272",
journal = "Scandinavian Journal of Infectious Diseases",
issn = "1651-1980",
publisher = "Informa Healthcare",
number = "4",

}