Clinical value of cerebrospinal fluid neurofilament light chain in semantic dementia

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Clinical value of cerebrospinal fluid neurofilament light chain in semantic dementia. / Meeter, Lieke H.H.; Steketee, Rebecca M.E.; Salkovic, Dina; Vos, Maartje E.; Grossman, Murray; McMillan, Corey T.; Irwin, David J.; Boxer, Adam L.; Rojas, Julio C.; Olney, Nicholas T.; Karydas, Anna; Miller, Bruce L.; Pijnenburg, Yolande A.L.; Barkhof, Frederik; Sánchez-Valle, Raquel; Lladó, Albert; Borrego-Ecija, Sergi; Diehl-Schmid, Janine; Grimmer, Timo; Goldhardt, Oliver; Santillo, Alexander F.; Hansson, Oskar; Vestberg, Susanne; Borroni, Barbara; Padovani, Alessandro; Galimberti, Daniela; Scarpini, Elio; Rohrer, Jonathan D.; Woollacott, Ione O.C.; Synofzik, Matthis; Wilke, Carlo; De Mendonca, Alexandre; Vandenberghe, Rik; Benussi, Luisa; Ghidoni, Roberta; Binetti, Giuliano; Niessen, Wiro J.; Papma, Janne M.; Seelaar, Harro; Jiskoot, Lize C.; De Jong, Frank Jan; Donker Kaat, Laura; Del Campo, Marta; Teunissen, Charlotte E.; Bron, Esther E.; Van Den Berg, Esther; Van Swieten, John C.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 90, No. 9, 2019, p. 997-1004.

Research output: Contribution to journalArticle

Harvard

Meeter, LHH, Steketee, RME, Salkovic, D, Vos, ME, Grossman, M, McMillan, CT, Irwin, DJ, Boxer, AL, Rojas, JC, Olney, NT, Karydas, A, Miller, BL, Pijnenburg, YAL, Barkhof, F, Sánchez-Valle, R, Lladó, A, Borrego-Ecija, S, Diehl-Schmid, J, Grimmer, T, Goldhardt, O, Santillo, AF, Hansson, O, Vestberg, S, Borroni, B, Padovani, A, Galimberti, D, Scarpini, E, Rohrer, JD, Woollacott, IOC, Synofzik, M, Wilke, C, De Mendonca, A, Vandenberghe, R, Benussi, L, Ghidoni, R, Binetti, G, Niessen, WJ, Papma, JM, Seelaar, H, Jiskoot, LC, De Jong, FJ, Donker Kaat, L, Del Campo, M, Teunissen, CE, Bron, EE, Van Den Berg, E & Van Swieten, JC 2019, 'Clinical value of cerebrospinal fluid neurofilament light chain in semantic dementia', Journal of Neurology, Neurosurgery and Psychiatry, vol. 90, no. 9, pp. 997-1004. https://doi.org/10.1136/jnnp-2018-319784

APA

Meeter, L. H. H., Steketee, R. M. E., Salkovic, D., Vos, M. E., Grossman, M., McMillan, C. T., Irwin, D. J., Boxer, A. L., Rojas, J. C., Olney, N. T., Karydas, A., Miller, B. L., Pijnenburg, Y. A. L., Barkhof, F., Sánchez-Valle, R., Lladó, A., Borrego-Ecija, S., Diehl-Schmid, J., Grimmer, T., ... Van Swieten, J. C. (2019). Clinical value of cerebrospinal fluid neurofilament light chain in semantic dementia. Journal of Neurology, Neurosurgery and Psychiatry, 90(9), 997-1004. https://doi.org/10.1136/jnnp-2018-319784

CBE

Meeter LHH, Steketee RME, Salkovic D, Vos ME, Grossman M, McMillan CT, Irwin DJ, Boxer AL, Rojas JC, Olney NT, Karydas A, Miller BL, Pijnenburg YAL, Barkhof F, Sánchez-Valle R, Lladó A, Borrego-Ecija S, Diehl-Schmid J, Grimmer T, Goldhardt O, Santillo AF, Hansson O, Vestberg S, Borroni B, Padovani A, Galimberti D, Scarpini E, Rohrer JD, Woollacott IOC, Synofzik M, Wilke C, De Mendonca A, Vandenberghe R, Benussi L, Ghidoni R, Binetti G, Niessen WJ, Papma JM, Seelaar H, Jiskoot LC, De Jong FJ, Donker Kaat L, Del Campo M, Teunissen CE, Bron EE, Van Den Berg E, Van Swieten JC. 2019. Clinical value of cerebrospinal fluid neurofilament light chain in semantic dementia. Journal of Neurology, Neurosurgery and Psychiatry. 90(9):997-1004. https://doi.org/10.1136/jnnp-2018-319784

MLA

Vancouver

Author

Meeter, Lieke H.H. ; Steketee, Rebecca M.E. ; Salkovic, Dina ; Vos, Maartje E. ; Grossman, Murray ; McMillan, Corey T. ; Irwin, David J. ; Boxer, Adam L. ; Rojas, Julio C. ; Olney, Nicholas T. ; Karydas, Anna ; Miller, Bruce L. ; Pijnenburg, Yolande A.L. ; Barkhof, Frederik ; Sánchez-Valle, Raquel ; Lladó, Albert ; Borrego-Ecija, Sergi ; Diehl-Schmid, Janine ; Grimmer, Timo ; Goldhardt, Oliver ; Santillo, Alexander F. ; Hansson, Oskar ; Vestberg, Susanne ; Borroni, Barbara ; Padovani, Alessandro ; Galimberti, Daniela ; Scarpini, Elio ; Rohrer, Jonathan D. ; Woollacott, Ione O.C. ; Synofzik, Matthis ; Wilke, Carlo ; De Mendonca, Alexandre ; Vandenberghe, Rik ; Benussi, Luisa ; Ghidoni, Roberta ; Binetti, Giuliano ; Niessen, Wiro J. ; Papma, Janne M. ; Seelaar, Harro ; Jiskoot, Lize C. ; De Jong, Frank Jan ; Donker Kaat, Laura ; Del Campo, Marta ; Teunissen, Charlotte E. ; Bron, Esther E. ; Van Den Berg, Esther ; Van Swieten, John C. / Clinical value of cerebrospinal fluid neurofilament light chain in semantic dementia. In: Journal of Neurology, Neurosurgery and Psychiatry. 2019 ; Vol. 90, No. 9. pp. 997-1004.

RIS

TY - JOUR

T1 - Clinical value of cerebrospinal fluid neurofilament light chain in semantic dementia

AU - Meeter, Lieke H.H.

AU - Steketee, Rebecca M.E.

AU - Salkovic, Dina

AU - Vos, Maartje E.

AU - Grossman, Murray

AU - McMillan, Corey T.

AU - Irwin, David J.

AU - Boxer, Adam L.

AU - Rojas, Julio C.

AU - Olney, Nicholas T.

AU - Karydas, Anna

AU - Miller, Bruce L.

AU - Pijnenburg, Yolande A.L.

AU - Barkhof, Frederik

AU - Sánchez-Valle, Raquel

AU - Lladó, Albert

AU - Borrego-Ecija, Sergi

AU - Diehl-Schmid, Janine

AU - Grimmer, Timo

AU - Goldhardt, Oliver

AU - Santillo, Alexander F.

AU - Hansson, Oskar

AU - Vestberg, Susanne

AU - Borroni, Barbara

AU - Padovani, Alessandro

AU - Galimberti, Daniela

AU - Scarpini, Elio

AU - Rohrer, Jonathan D.

AU - Woollacott, Ione O.C.

AU - Synofzik, Matthis

AU - Wilke, Carlo

AU - De Mendonca, Alexandre

AU - Vandenberghe, Rik

AU - Benussi, Luisa

AU - Ghidoni, Roberta

AU - Binetti, Giuliano

AU - Niessen, Wiro J.

AU - Papma, Janne M.

AU - Seelaar, Harro

AU - Jiskoot, Lize C.

AU - De Jong, Frank Jan

AU - Donker Kaat, Laura

AU - Del Campo, Marta

AU - Teunissen, Charlotte E.

AU - Bron, Esther E.

AU - Van Den Berg, Esther

AU - Van Swieten, John C.

PY - 2019

Y1 - 2019

N2 - Background: Semantic dementia (SD) is a neurodegenerative disorder characterised by progressive language problems falling within the clinicopathological spectrum of frontotemporal lobar degeneration (FTLD). The development of disease-modifying agents may be facilitated by the relative clinical and pathological homogeneity of SD, but we need robust monitoring biomarkers to measure their efficacy. In different FTLD subtypes, neurofilament light chain (NfL) is a promising marker, therefore we investigated the utility of cerebrospinal fluid (CSF) NfL in SD. Methods: This large retrospective multicentre study compared cross-sectional CSF NfL levels of 162 patients with SD with 65 controls. CSF NfL levels of patients were correlated with clinical parameters (including survival), neuropsychological test scores and regional grey matter atrophy (including longitudinal data in a subset). Results: CSF NfL levels were significantly higher in patients with SD (median: 2326 pg/mL, IQR: 1628-3593) than in controls (577 (446-766), p<0.001). Higher CSF NfL levels were moderately associated with naming impairment as measured by the Boston Naming Test (rs=-0.32, p=0.002) and with smaller grey matter volume of the parahippocampal gyri (rs=-0.31, p=0.004). However, cross-sectional CSF NfL levels were not associated with progression of grey matter atrophy and did not predict survival. Conclusion: CSF NfL is a promising biomarker in the diagnostic process of SD, although it has limited cross-sectional monitoring or prognostic abilities.

AB - Background: Semantic dementia (SD) is a neurodegenerative disorder characterised by progressive language problems falling within the clinicopathological spectrum of frontotemporal lobar degeneration (FTLD). The development of disease-modifying agents may be facilitated by the relative clinical and pathological homogeneity of SD, but we need robust monitoring biomarkers to measure their efficacy. In different FTLD subtypes, neurofilament light chain (NfL) is a promising marker, therefore we investigated the utility of cerebrospinal fluid (CSF) NfL in SD. Methods: This large retrospective multicentre study compared cross-sectional CSF NfL levels of 162 patients with SD with 65 controls. CSF NfL levels of patients were correlated with clinical parameters (including survival), neuropsychological test scores and regional grey matter atrophy (including longitudinal data in a subset). Results: CSF NfL levels were significantly higher in patients with SD (median: 2326 pg/mL, IQR: 1628-3593) than in controls (577 (446-766), p<0.001). Higher CSF NfL levels were moderately associated with naming impairment as measured by the Boston Naming Test (rs=-0.32, p=0.002) and with smaller grey matter volume of the parahippocampal gyri (rs=-0.31, p=0.004). However, cross-sectional CSF NfL levels were not associated with progression of grey matter atrophy and did not predict survival. Conclusion: CSF NfL is a promising biomarker in the diagnostic process of SD, although it has limited cross-sectional monitoring or prognostic abilities.

U2 - 10.1136/jnnp-2018-319784

DO - 10.1136/jnnp-2018-319784

M3 - Article

C2 - 31123142

AN - SCOPUS:85066140649

VL - 90

SP - 997

EP - 1004

JO - Journal of Neurology, Neurosurgery and Psychiatry

JF - Journal of Neurology, Neurosurgery and Psychiatry

SN - 1468-330X

IS - 9

ER -