Closed-loop regulation of arterial pressure after acute brain death
Research output: Contribution to journal › Article
Method: A dynamic model of nitroglycerine pharmacology, suitable for controller synthesis, was identified from an experiment involving an anesthetized pig, using a gradient-based output error method. The model was used to synthesize a robust PID controller for hypertension prevention, evaluated in a second experiment, on a second, brain dead, pig. Hypotension was simultaneously prevented using closed-loop controlled infusion of noradrenaline, by means of a previously published controller.
Results: A linear model of low order, with variable (uncertain) gain, was sufficient to describe the dynamics to be controlled. The robustly tuned PID controller utilized in the second experiment kept the MAP within a user-defined range. The system was able to prevent hypertension, exceeding a reference of 100 mmHg by more than 10 %, during 98 % of a 12 h experiment.
Conclusion: This early work demonstrates feasibility of the investigated modelling and control synthesis approach, for the purpose of maintaining normotension in a porcine BD model. There remains a need to characterize individual variability, in order to ensure robust performance over the expected population.
|Research areas and keywords||
Subject classification (UKÄ) – MANDATORY
|Journal||Journal of Clinical Monitoring and Computing|
|Publication status||Published - 2018|
Anders Holmqvist, Niklas Andersson, Anton Cervin, Anders Mannesson, Ather Gattami, Andrey Ghulchak, Alessandro Vittorio Papadopoulos, Anders Rantzer, Anders Robertsson, Aivar Sootla, ALFRED THEORIN, Bo Bernhardsson, Björn Olofsson, Björn Wittenmark, Christian Grussler, Charlotta Johnsson, Daria Madjidian, Erik Johannesson, Fredrik Magnusson, Fredrik Ståhl, Giacomo Como, Georgios Chasparis, Gabriel Turesson, Isolde Dressler, Johan Åkesson, Jang Ho Cho, Karl-Erik Årzén, Karl Johan Åström, Kin Cheong Sou, Karl Mårtensson, Karl Berntorp, Kristian Soltesz, Laurent Lessard, Martin Hast, Meike Rönn, Martin Ansbjerg Kjær, Martina Maggio, Maxim Kristalny, Olof Garpinger, Pål Johan From, Per-Ola Larsson, Pontus Giselsson, Rolf Johansson, Tore Hägglund, Vladimeros Vladimerou, Vanessa Romero Segovia, Andreas Aurelius, Gustav Cedersjö, Kaan Bür, Manfred Dellkrantz, Manxing Du, Payam Amani, Robin Larsson, William Tärneberg, Zheng Li, Lianhao Yin, Fredrik Tufvesson, Stefan Höst, Bernt Nilsson, Stig Stenström, Jens A Andersson, Stefan Diehl, Jonas Dürango, Mahdi Ghazaei Ardakani, Per-Ola Forsberg, Fredrik Bengtsson, Henrik Jörntell, Carmen Arévalo, Claus Führer, Christian Andersson, Fatemeh Mohammadi, Per Ödling, Mikael Andersson, Maria Kihl & Per Tunestål
2008/07/01 → 2018/06/30