Closure of atrial septal defect in the adult. Cardiac remodeling is an early event.

Research output: Contribution to journalArticle


Background: Study aimed to describe the extent and the temporal profile of cardiac remodeling after atrial septal defect closure in the adult. Methods: Prospective and longitudinal echocardiographic assessment of right and left heart size before and after (1 day-1 week/1/4/12 months) surgical or catheter-based atrial septal closure in 39 adults (age 54 15 years). Results: Right ventricular and atrial sizes were markedly reduced, left ventricular size increased and left atrial size remained unchanged after closure. Older age and a history of atrial fibrillation reduced the potential to normalize right and left atrial size after closure. The greater part of the changes occurred very early, in the 1st day/1st week, From then on the speed of change gradually diminished and after 4 months no important changes were observed. The mode of closure did not influence the degree or the pace of the remodeling. Conclusion: Cardiac remodeling after atrial septal closure in the adult is a common and early event that seems by and large completed within the first half year after closure. The ventricles seem to have a higher capacity of remodeling than the atria in this setting. The mode of closure does not seem to significantly impact remodeling. (c) 2005 Elsevier Ireland Ltd. All rights reserved.


  • Ulf Thilén
  • S Persson
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cardiac and Cardiovascular Systems


  • atrial septal defect, congenital heart disease, remodeling, adult, closure
Original languageEnglish
Pages (from-to)370-375
JournalInternational Journal of Cardiology
Issue number3
Publication statusPublished - 2006
Publication categoryResearch

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Ulf Thilén, 2009, Department of Cardiology, Clinical sciences, Lund University. 68 p.

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