Closure of atrial septal defect in the adult. Cardiac remodeling is an early event.

Research output: Contribution to journalArticle

Abstract

Background: Study aimed to describe the extent and the temporal profile of cardiac remodeling after atrial septal defect closure in the adult. Methods: Prospective and longitudinal echocardiographic assessment of right and left heart size before and after (1 day-1 week/1/4/12 months) surgical or catheter-based atrial septal closure in 39 adults (age 54 15 years). Results: Right ventricular and atrial sizes were markedly reduced, left ventricular size increased and left atrial size remained unchanged after closure. Older age and a history of atrial fibrillation reduced the potential to normalize right and left atrial size after closure. The greater part of the changes occurred very early, in the 1st day/1st week, From then on the speed of change gradually diminished and after 4 months no important changes were observed. The mode of closure did not influence the degree or the pace of the remodeling. Conclusion: Cardiac remodeling after atrial septal closure in the adult is a common and early event that seems by and large completed within the first half year after closure. The ventricles seem to have a higher capacity of remodeling than the atria in this setting. The mode of closure does not seem to significantly impact remodeling. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

Details

Authors
  • Ulf Thilén
  • S Persson
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cardiac and Cardiovascular Systems

Keywords

  • atrial septal defect, congenital heart disease, remodeling, adult, closure
Original languageEnglish
Pages (from-to)370-375
JournalInternational Journal of Cardiology
Volume108
Issue number3
Publication statusPublished - 2006
Publication categoryResearch
Peer-reviewedYes

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Related research output

Ulf Thilén, 2009, Department of Cardiology, Clinical sciences, Lund University. 68 p.

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