Cognitive function in young adults following intrauterine growth restriction with abnormal fetal aortic blood flow.

Research output: Contribution to journalArticle

Abstract

Objective
Intrauterine growth restriction (IUGR) is a recognized risk factor for neurological deficits later in life. Abnormal fetal blood flow in the presence of IUGR helps to distinguish fetuses with true growth impairment from those that are small but normally grown. This study aimed to evaluate the influence of IUGR with abnormal fetal blood flow on cognitive function and psychological development in young adults.
Methods
Cognitive capacity (Wechsler adult intelligence scale-III (WAIS-III)) and psychological development (symptom check-list and Wender Utah rating scale) were evaluated at 18 years of age in 19 subjects who had had IUGR (abnormal fetal blood flow in the descending aorta and birth weight small-for-gestational age) and in 23 control subjects who had had normal fetal aortic blood flow and birth weight appropriate-for-gestational age (AGA). School grades at 16 years of age were also recorded.
Results
The IUGR subjects had significantly lower results at 18 years of age in the combined subtests of the WAIS-III measuring executive cognitive functions (P = 0.03) and lower school grades at 16 years of age (P = 0.03) compared with the AGA group. IUGR subjects did not exhibit significantly more psychological distress symptoms.
Conclusion
IUGR with abnormal fetal blood flow is associated with impaired executive cognitive function in young adults.

Details

Authors
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Radiology, Nuclear Medicine and Medical Imaging

Keywords

  • fetal blood flow, long-term follow-up, psychological development, intrauterine growth restriction, small for gestational age, cognitive outcome
Original languageEnglish
Pages (from-to)614-618
JournalUltrasound in Obstetrics & Gynecology
Volume29
Issue number6
Publication statusPublished - 2007
Publication categoryResearch
Peer-reviewedYes