Cognitively normal women with Alzheimer's disease proteinopathy show relative preservation of memory but not of hippocampal volume

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@article{ab7e670f68514bafaefcaec7d160accf,
title = "Cognitively normal women with Alzheimer's disease proteinopathy show relative preservation of memory but not of hippocampal volume",
abstract = "BACKGROUND: We examined interactive effects of sex, diagnosis, and cerebrospinal fluid (CSF) amyloid beta/phosphorylated tau ratio (Aβ/P-tau) on verbal memory and hippocampal volumes. METHODS: We assessed 682 participants (350 women) from BioFINDER (250 cognitively normal [CN]; and 432 symptomatic: 186 subjective cognitive decline [SCD], 246 mild cognitive impairment [MCI]). General linear models evaluated effects of Alzheimer's disease (AD) proteinopathy (CSF A{\ss}/p-tau ratio), diagnosis, and sex on verbal memory (ADAS-cog 10-word recall), semantic fluency (animal naming fluency), visuospatial skills (cube copy), processing speed/attention functions (Symbol Digit Modalities Test and Trail Making Part A), and hippocampal volumes. RESULTS: Amyloid-positive (Aβ/P-tau+) CN women (women with preclinical AD) showed memory equivalent to amyloid-negative (Aβ/P-tau-) CN women. In contrast, Aβ/P-tau+ CN men (men with preclinical AD) showed poorer memory than Aβ/P-tau- CN men. Symptomatic groups showed no sex differences in effect of AD proteinopathy on memory. There was no interactive effect of sex, diagnosis, and Aβ/P-tau on other measures of cognition or on hippocampal volume. CONCLUSIONS: CN women show relatively preserved verbal memory, but not general cognitive reserve or preserved hippocampal volume in the presence of Aβ/P-tau+. Results have implications for diagnosing AD in women, and for clinical trials.",
keywords = "Hippocampus, Mild cognitive impairment, Sex, Subjective cognitive decline, Verbal memory, Women",
author = "Caldwell, {Jessica Z.K.} and Cummings, {Jeffrey L.} and Banks, {Sarah J.} and Sebastian Palmqvist and Oskar Hansson",
year = "2019",
month = "12",
day = "26",
doi = "10.1186/s13195-019-0565-1",
language = "English",
volume = "11",
journal = "Alzheimer's Research & Therapy",
issn = "1758-9193",
publisher = "BioMed Central (BMC)",
number = "1",

}