Collagen VI Is a Subepithelial Adhesive Target for Human Respiratory Tract Pathogens

Research output: Contribution to journalArticle

Abstract

Bacterial engagement of specific host tissue structures can be a means of targeting a pathogen to a particular niche, establishing persistent infections and inducing invasion. In this context, primary adhesion is often the first crucial colonization step allowing pathogens to withstand the mechanical clearing mechanisms of the host. As a consequence, bacteria have evolved adhesins with the capacity to mediate interaction between microorganism and host. Here we describe Collagen VI as a novel target for adherence of Streptococcus pyogenes and Streptococcus pneumoniae. In upper and lower airways this Collagen was distributed in the lamina propria underneath the epithelial basement membrane. Both pathogens exhibited strong affinity to Collagen VI as shown by light and electron microscopy in combination with immunodetection and in vitro binding assays. For S. pyogenes this interaction was mediated by M1 protein. The presented data provide evidence for a previously unrecognized role for Collagen VI in host-pathogen interplay during respiratory tract infection. Copyright (C) 2009 S. Karger AG, Basel

Details

Authors
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Infectious Medicine

Keywords

  • Respiratory infection, adhesion, Primary, Host-pathogen interaction, Collagen VI, Adhesin, Airways, Respiratory pathogen, Streptococcus
Original languageEnglish
Pages (from-to)160-166
JournalJournal of Innate Immunity
Volume2
Issue number2
Publication statusPublished - 2010
Publication categoryResearch
Peer-reviewedYes

Related research output

Bober, M., 2011, Division of Infection Medicine. 122 p.

Research output: ThesisDoctoral Thesis (compilation)

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