Comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'
Research output: Contribution to journal › Article
The AIRE gene plays a key role in the development of central immune tolerance by promoting thymic presentation of tissue-specific molecules. Patients with AIRE-deficiency develop multiple autoimmune manifestations and display autoantibodies against the affected tissues. In 2016 it was reported that: i) the spectrum of autoantibodies in patients with AIRE-deficiency is much broader than previously appreciated; ii) neutralizing autoantibodies to type I interferons (IFNs) could provide protection against type 1 diabetes in these patients (Meyer et al., 2016). We attempted to replicate these new findings using a similar experimental approach in an independent patient cohort, and found no evidence for either conclusion.
|Research areas and keywords||
Subject classification (UKÄ) – MANDATORY
|Publication status||E-pub ahead of print - 2019 Jun 27|