Comment on "The mechanism for activation of GTP hydrolysis on the ribosome".
Research output: Contribution to journal › Article
Voorhees et al. (Reports, 5 November 2010, p. 835) determined the structure of elongation factor Tu (EF-Tu) and aminoacyl-transfer RNA bound to the ribosome with a guanosine triphosphate (GTP) analog. However, their identification of histidine-84 of EF-Tu as deprotonating the catalytic water molecule is problematic in relation to their atomic structure; the terminal phosphate of GTP is more likely to be the proper proton acceptor.
|Research areas and keywords||
Subject classification (UKÄ) – MANDATORY
|Pages (from-to)||37; author reply 37|
|Publication status||Published - 2011|