Common Breast Cancer Susceptibility Loci Are Associated with Triple-Negative Breast Cancer

Research output: Contribution to journalArticle

Abstract

Triple-negative breast cancers are an aggressive subtype of breast cancer with poor survival, but there remains little known about the etiologic factors that promote its initiation and development. Commonly inherited breast cancer risk factors identified through genome-wide association studies display heterogeneity of effect among breast cancer subtypes as defined by the status of estrogen and progesterone receptors. In the Triple Negative Breast Cancer Consortium (TNBCC), 22 common breast cancer susceptibility variants were investigated in 2,980 Caucasian women with triple-negative breast cancer and 4,978 healthy controls. We identified six single-nucleotide polymorphisms, including rs2046210 (ESR1), rs12662670 (ESR1), rs3803662 (TOX3), rs999737 (RAD51L1), rs8170 (19p13.1), and rs8100241 (19p13.1), significantly associated with the risk of triple-negative breast cancer. Together, our results provide convincing evidence of genetic susceptibility for triple-negative breast cancer. Cancer Res; 71(19); 6240-9. (C)2011 AACR.

Details

Authors
  • Kristen N. Stevens
  • Celine M. Vachon
  • Adam M. Lee
  • Susan Slager
  • Timothy Lesnick
  • Curtis Olswold
  • Peter A. Fasching
  • Penelope Miron
  • Diana Eccles
  • Jane E. Carpenter
  • Andrew K. Godwin
  • Christine Ambrosone
  • Robert Winqvist
  • Hiltrud Brauch
  • Marjanka K. Schmidt
  • Angela Cox
  • Simon S. Cross
  • Elinor Sawyer
  • Arndt Hartmann
  • Matthias W. Beckmann
  • Ruediger Schulz-Wendtland
  • Arif B. Ekici
  • William J. Tapper
  • Susan M. Gerty
  • Lorraine Durcan
  • Nikki Graham
  • Rebecca Hein
  • Stephan Nickels
  • Dieter Flesch-Janys
  • Judith Heinz
  • Hans-Peter Sinn
  • Irene Konstantopoulou
  • Florentia Fostira
  • Dimitrios Pectasides
  • Athanasios M. Dimopoulos
  • George Fountzilas
  • Christine L. Clarke
  • Rosemary Balleine
  • Janet E. Olson
  • Zachary Fredericksen
  • Robert B. Diasio
  • Harsh Pathak
  • Eric Ross
  • JoEllen Weaver
  • Thomas Ruediger
  • Thomas Duennebier
  • Foluso Ademuyiwa
  • Swati Kulkarni
  • Katri Pylkaes
  • Arja Jukkola-Vuorinen
  • Yon-Dschun Ko
  • Erik Van Limbergen
  • Hilde Janssen
  • Julian Peto
  • Olivia Fletcher
  • Graham G. Giles
  • Laura Baglietto
  • Senno Verhoef
  • Ian Tomlinson
  • Veli-Matti Kosma
  • Jonathan Beesley
  • Dario Greco
  • Carl Blomqvist
  • Astrid Irwanto
  • Jianjun Liu
  • Fiona M. Blows
  • Sarah-Jane Dawson
  • Sara Margolin
  • Arto Mannermaa
  • Nicholas G. Martin
  • Grant W. Montgomery
  • Diether Lambrechts
  • Isabel dos Santos Silva
  • Gianluca Severi
  • Ute Hamann
  • Paul Pharoah
  • Douglas F. Easton
  • Jenny Chang-Claude
  • Drakoulis Yannoukakos
  • Heli Nevanlinna
  • Xianshu Wang
  • Fergus J. Couch
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Public Health, Global Health, Social Medicine and Epidemiology
Original languageEnglish
Pages (from-to)6240-6249
JournalCancer Research
Volume71
Issue number19
Publication statusPublished - 2011
Publication categoryResearch
Peer-reviewedYes