Common Breast Cancer Susceptibility Loci Are Associated with Triple-Negative Breast Cancer

Research output: Contribution to journalArticle


title = "Common Breast Cancer Susceptibility Loci Are Associated with Triple-Negative Breast Cancer",
abstract = "Triple-negative breast cancers are an aggressive subtype of breast cancer with poor survival, but there remains little known about the etiologic factors that promote its initiation and development. Commonly inherited breast cancer risk factors identified through genome-wide association studies display heterogeneity of effect among breast cancer subtypes as defined by the status of estrogen and progesterone receptors. In the Triple Negative Breast Cancer Consortium (TNBCC), 22 common breast cancer susceptibility variants were investigated in 2,980 Caucasian women with triple-negative breast cancer and 4,978 healthy controls. We identified six single-nucleotide polymorphisms, including rs2046210 (ESR1), rs12662670 (ESR1), rs3803662 (TOX3), rs999737 (RAD51L1), rs8170 (19p13.1), and rs8100241 (19p13.1), significantly associated with the risk of triple-negative breast cancer. Together, our results provide convincing evidence of genetic susceptibility for triple-negative breast cancer. Cancer Res; 71(19); 6240-9. (C)2011 AACR.",
author = "Stevens, {Kristen N.} and Vachon, {Celine M.} and Lee, {Adam M.} and Susan Slager and Timothy Lesnick and Curtis Olswold and Fasching, {Peter A.} and Penelope Miron and Diana Eccles and Carpenter, {Jane E.} and Godwin, {Andrew K.} and Christine Ambrosone and Robert Winqvist and Hiltrud Brauch and Schmidt, {Marjanka K.} and Angela Cox and Cross, {Simon S.} and Elinor Sawyer and Arndt Hartmann and Beckmann, {Matthias W.} and Ruediger Schulz-Wendtland and Ekici, {Arif B.} and Tapper, {William J.} and Gerty, {Susan M.} and Lorraine Durcan and Nikki Graham and Rebecca Hein and Stephan Nickels and Dieter Flesch-Janys and Judith Heinz and Hans-Peter Sinn and Irene Konstantopoulou and Florentia Fostira and Dimitrios Pectasides and Dimopoulos, {Athanasios M.} and George Fountzilas and Clarke, {Christine L.} and Rosemary Balleine and Olson, {Janet E.} and Zachary Fredericksen and Diasio, {Robert B.} and Harsh Pathak and Eric Ross and JoEllen Weaver and Thomas Ruediger and Asta F{\"o}rsti and Thomas Duennebier and Foluso Ademuyiwa and Swati Kulkarni and Katri Pylkaes and Arja Jukkola-Vuorinen and Yon-Dschun Ko and {Van Limbergen}, Erik and Hilde Janssen and Julian Peto and Olivia Fletcher and Giles, {Graham G.} and Laura Baglietto and Senno Verhoef and Ian Tomlinson and Veli-Matti Kosma and Jonathan Beesley and Dario Greco and Carl Blomqvist and Astrid Irwanto and Jianjun Liu and Blows, {Fiona M.} and Sarah-Jane Dawson and Sara Margolin and Arto Mannermaa and Martin, {Nicholas G.} and Montgomery, {Grant W.} and Diether Lambrechts and Silva, {Isabel dos Santos} and Gianluca Severi and Ute Hamann and Paul Pharoah and Easton, {Douglas F.} and Jenny Chang-Claude and Drakoulis Yannoukakos and Heli Nevanlinna and Xianshu Wang and Couch, {Fergus J.}",
year = "2011",
doi = "10.1158/0008-5472.CAN-11-1266",
language = "English",
volume = "71",
pages = "6240--6249",
journal = "Cancer research. Supplement",
issn = "1538-7445",
publisher = "American Association for Cancer Research Inc.",
number = "19",