Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers

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Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers. / Antoniou, Antonis C.; Kuchenbaecker, Karoline B.; Soucy, Penny; Beesley, Jonathan; Chen, Xiaoqing; McGuffog, Lesley; Lee, Andrew; Barrowdale, Daniel; Healey, Sue; Sinilnikova, Olga M.; Caligo, Maria A.; Loman, Niklas; Harbst, Katja; Lindblom, Annika; Arver, Brita; Rosenquist, Richard; Karlsson, Per; Nathanson, Kate; Domchek, Susan; Rebbeck, Tim; Jakubowska, Anna; Lubinski, Jan; Jaworska, Katarzyna; Durda, Katarzyna; Zlowowcka-Perlowska, Elzbieta; Osorio, Ana; Duran, Mercedes; Andres, Raquel; Benitez, Javier; Hamann, Ute; Hogervorst, Frans B.; van Os, Theo A.; Verhoef, Senno; Meijers-Heijboer, Hanne E. J.; Wijnen, Juul; Garcia, Encarna B. Gomez; Ligtenberg, Marjolijn J.; Kriege, Mieke; Collee, Margriet; Ausems, Margreet G. E. M.; Oosterwijk, Jan C.; Peock, Susan; Frost, Debra; Ellis, Steve D.; Platte, Radka; Fineberg, Elena; Evans, D. Gareth; Lalloo, Fiona; Jacobs, Chris; Eeles, Ros; Adlard, Julian; Davidson, Rosemarie; Cole, Trevor; Cook, Jackie; Paterson, Joan; Douglas, Fiona; Brewer, Carole; Hodgson, Shirley; Morrison, Patrick J.; Walker, Lisa; Rogers, Mark T.; Donaldson, Alan; Dorkins, Huw; Godwin, Andrew K.; Bove, Betsy; Stoppa-Lyonnet, Dominique; Houdayer, Claude; Buecher, Bruno; de Pauw, Antoine; Mazoyer, Sylvie; Calender, Alain; Leone, Melanie; Bressac-de Paillerets, Brigitte; Caron, Olivier; Sobol, Hagay; Frenay, Marc; Prieur, Fabienne; Ferrer, Sandra Fert; Mortemousque, Isabelle; Buys, Saundra; Daly, Mary; Miron, Alexander; Terry, Mary Beth; Hopper, John L.; John, Esther M.; Southey, Melissa; Goldgar, David; Singer, Christian F.; Fink-Retter, Anneliese; Tea, Muy-Kheng; Kaulich, Daphne Geschwantler; Hansen, Thomas V. O.; Nielsen, Finn C.; Barkardottir, Rosa B.; Gaudet, Mia; Kirchhoff, Tomas; Joseph, Vijai; Dutra-Clarke, Ana; Offit, Kenneth; Piedmonte, Marion; Kirk, Judy; Cohn, David; Hurteau, Jean; Byron, John; Fiorica, James; Toland, Amanda E.; Montagna, Marco; Oliani, Cristina; Imyanitov, Evgeny; Isaacs, Claudine; Tihomirova, Laima; Blanco, Ignacio; Lazaro, Conxi; Teule, Alex; Del Valle, J.; Gayther, Simon A.; Odunsi, Kunle; Gross, Jenny; Karlan, Beth Y.; Olah, Edith; Teo, Soo-Hwang; Ganz, Patricia A.; Beattie, Mary S.; Dorfling, Cecelia M.; van Rensburg, Elizabeth Jansen; Diez, Orland; Kwong, Ava; Schmutzler, Rita K.; Wappenschmidt, Barbara; Engel, Christoph; Meindl, Alfons; Ditsch, Nina; Arnold, Norbert; Heidemann, Simone; Niederacher, Dieter; Preisler-Adams, Sabine; Gadzicki, Dorothea; Varon-Mateeva, Raymonda; Deissler, Helmut; Gehrig, Andrea; Sutter, Christian; Kast, Karin; Fiebig, Britta; Schaefer, Dieter; Caldes, Trinidad; de la Hoya, Miguel; Nevanlinna, Heli; Muranen, Taru A.; Lesperance, Bernard; Spurdle, Amanda B.; Neuhausen, Susan L.; Ding, Yuan C.; Wang, Xianshu; Fredericksen, Zachary; Pankratz, Vernon S.; Lindor, Noralane M.; Peterlongo, Paolo; Manoukian, Siranoush; Peissel, Bernard; Zaffaroni, Daniela; Bonanni, Bernardo; Bernard, Loris; Dolcetti, Riccardo; Papi, Laura; Ottini, Laura; Radice, Paolo; Greene, Mark H.; Loud, Jennifer T.; Andrulis, Irene L.; Ozcelik, Hilmi; Mulligan, Anna Marie; Glendon, Gord; Thomassen, Mads; Gerdes, Anne-Marie; Jensen, Uffe B.; Skytte, Anne-Bine; Kruse, Torben A.; Chenevix-Trench, Georgia; Couch, Fergus J.; Simard, Jacques; Easton, Douglas F.

In: Breast Cancer Research, Vol. 14, No. 1, 2012.

Research output: Contribution to journalArticle

Harvard

Antoniou, AC, Kuchenbaecker, KB, Soucy, P, Beesley, J, Chen, X, McGuffog, L, Lee, A, Barrowdale, D, Healey, S, Sinilnikova, OM, Caligo, MA, Loman, N, Harbst, K, Lindblom, A, Arver, B, Rosenquist, R, Karlsson, P, Nathanson, K, Domchek, S, Rebbeck, T, Jakubowska, A, Lubinski, J, Jaworska, K, Durda, K, Zlowowcka-Perlowska, E, Osorio, A, Duran, M, Andres, R, Benitez, J, Hamann, U, Hogervorst, FB, van Os, TA, Verhoef, S, Meijers-Heijboer, HEJ, Wijnen, J, Garcia, EBG, Ligtenberg, MJ, Kriege, M, Collee, M, Ausems, MGEM, Oosterwijk, JC, Peock, S, Frost, D, Ellis, SD, Platte, R, Fineberg, E, Evans, DG, Lalloo, F, Jacobs, C, Eeles, R, Adlard, J, Davidson, R, Cole, T, Cook, J, Paterson, J, Douglas, F, Brewer, C, Hodgson, S, Morrison, PJ, Walker, L, Rogers, MT, Donaldson, A, Dorkins, H, Godwin, AK, Bove, B, Stoppa-Lyonnet, D, Houdayer, C, Buecher, B, de Pauw, A, Mazoyer, S, Calender, A, Leone, M, Bressac-de Paillerets, B, Caron, O, Sobol, H, Frenay, M, Prieur, F, Ferrer, SF, Mortemousque, I, Buys, S, Daly, M, Miron, A, Terry, MB, Hopper, JL, John, EM, Southey, M, Goldgar, D, Singer, CF, Fink-Retter, A, Tea, M-K, Kaulich, DG, Hansen, TVO, Nielsen, FC, Barkardottir, RB, Gaudet, M, Kirchhoff, T, Joseph, V, Dutra-Clarke, A, Offit, K, Piedmonte, M, Kirk, J, Cohn, D, Hurteau, J, Byron, J, Fiorica, J, Toland, AE, Montagna, M, Oliani, C, Imyanitov, E, Isaacs, C, Tihomirova, L, Blanco, I, Lazaro, C, Teule, A, Del Valle, J, Gayther, SA, Odunsi, K, Gross, J, Karlan, BY, Olah, E, Teo, S-H, Ganz, PA, Beattie, MS, Dorfling, CM, van Rensburg, EJ, Diez, O, Kwong, A, Schmutzler, RK, Wappenschmidt, B, Engel, C, Meindl, A, Ditsch, N, Arnold, N, Heidemann, S, Niederacher, D, Preisler-Adams, S, Gadzicki, D, Varon-Mateeva, R, Deissler, H, Gehrig, A, Sutter, C, Kast, K, Fiebig, B, Schaefer, D, Caldes, T, de la Hoya, M, Nevanlinna, H, Muranen, TA, Lesperance, B, Spurdle, AB, Neuhausen, SL, Ding, YC, Wang, X, Fredericksen, Z, Pankratz, VS, Lindor, NM, Peterlongo, P, Manoukian, S, Peissel, B, Zaffaroni, D, Bonanni, B, Bernard, L, Dolcetti, R, Papi, L, Ottini, L, Radice, P, Greene, MH, Loud, JT, Andrulis, IL, Ozcelik, H, Mulligan, AM, Glendon, G, Thomassen, M, Gerdes, A-M, Jensen, UB, Skytte, A-B, Kruse, TA, Chenevix-Trench, G, Couch, FJ, Simard, J & Easton, DF 2012, 'Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers', Breast Cancer Research, vol. 14, no. 1. https://doi.org/10.1186/bcr3121

APA

Antoniou, A. C., Kuchenbaecker, K. B., Soucy, P., Beesley, J., Chen, X., McGuffog, L., Lee, A., Barrowdale, D., Healey, S., Sinilnikova, O. M., Caligo, M. A., Loman, N., Harbst, K., Lindblom, A., Arver, B., Rosenquist, R., Karlsson, P., Nathanson, K., Domchek, S., ... Easton, D. F. (2012). Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers. Breast Cancer Research, 14(1). https://doi.org/10.1186/bcr3121

CBE

Antoniou AC, Kuchenbaecker KB, Soucy P, Beesley J, Chen X, McGuffog L, Lee A, Barrowdale D, Healey S, Sinilnikova OM, Caligo MA, Loman N, Harbst K, Lindblom A, Arver B, Rosenquist R, Karlsson P, Nathanson K, Domchek S, Rebbeck T, Jakubowska A, Lubinski J, Jaworska K, Durda K, Zlowowcka-Perlowska E, Osorio A, Duran M, Andres R, Benitez J, Hamann U, Hogervorst FB, van Os TA, Verhoef S, Meijers-Heijboer HEJ, Wijnen J, Garcia EBG, Ligtenberg MJ, Kriege M, Collee M, Ausems MGEM, Oosterwijk JC, Peock S, Frost D, Ellis SD, Platte R, Fineberg E, Evans DG, Lalloo F, Jacobs C, Eeles R, Adlard J, Davidson R, Cole T, Cook J, Paterson J, Douglas F, Brewer C, Hodgson S, Morrison PJ, Walker L, Rogers MT, Donaldson A, Dorkins H, Godwin AK, Bove B, Stoppa-Lyonnet D, Houdayer C, Buecher B, de Pauw A, Mazoyer S, Calender A, Leone M, Bressac-de Paillerets B, Caron O, Sobol H, Frenay M, Prieur F, Ferrer SF, Mortemousque I, Buys S, Daly M, Miron A, Terry MB, Hopper JL, John EM, Southey M, Goldgar D, Singer CF, Fink-Retter A, Tea M-K, Kaulich DG, Hansen TVO, Nielsen FC, Barkardottir RB, Gaudet M, Kirchhoff T, Joseph V, Dutra-Clarke A, Offit K, Piedmonte M, Kirk J, Cohn D, Hurteau J, Byron J, Fiorica J, Toland AE, Montagna M, Oliani C, Imyanitov E, Isaacs C, Tihomirova L, Blanco I, Lazaro C, Teule A, Del Valle J, Gayther SA, Odunsi K, Gross J, Karlan BY, Olah E, Teo S-H, Ganz PA, Beattie MS, Dorfling CM, van Rensburg EJ, Diez O, Kwong A, Schmutzler RK, Wappenschmidt B, Engel C, Meindl A, Ditsch N, Arnold N, Heidemann S, Niederacher D, Preisler-Adams S, Gadzicki D, Varon-Mateeva R, Deissler H, Gehrig A, Sutter C, Kast K, Fiebig B, Schaefer D, Caldes T, de la Hoya M, Nevanlinna H, Muranen TA, Lesperance B, Spurdle AB, Neuhausen SL, Ding YC, Wang X, Fredericksen Z, Pankratz VS, Lindor NM, Peterlongo P, Manoukian S, Peissel B, Zaffaroni D, Bonanni B, Bernard L, Dolcetti R, Papi L, Ottini L, Radice P, Greene MH, Loud JT, Andrulis IL, Ozcelik H, Mulligan AM, Glendon G, Thomassen M, Gerdes A-M, Jensen UB, Skytte A-B, Kruse TA, Chenevix-Trench G, Couch FJ, Simard J, Easton DF. 2012. Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers. Breast Cancer Research. 14(1). https://doi.org/10.1186/bcr3121

MLA

Vancouver

Author

Antoniou, Antonis C. ; Kuchenbaecker, Karoline B. ; Soucy, Penny ; Beesley, Jonathan ; Chen, Xiaoqing ; McGuffog, Lesley ; Lee, Andrew ; Barrowdale, Daniel ; Healey, Sue ; Sinilnikova, Olga M. ; Caligo, Maria A. ; Loman, Niklas ; Harbst, Katja ; Lindblom, Annika ; Arver, Brita ; Rosenquist, Richard ; Karlsson, Per ; Nathanson, Kate ; Domchek, Susan ; Rebbeck, Tim ; Jakubowska, Anna ; Lubinski, Jan ; Jaworska, Katarzyna ; Durda, Katarzyna ; Zlowowcka-Perlowska, Elzbieta ; Osorio, Ana ; Duran, Mercedes ; Andres, Raquel ; Benitez, Javier ; Hamann, Ute ; Hogervorst, Frans B. ; van Os, Theo A. ; Verhoef, Senno ; Meijers-Heijboer, Hanne E. J. ; Wijnen, Juul ; Garcia, Encarna B. Gomez ; Ligtenberg, Marjolijn J. ; Kriege, Mieke ; Collee, Margriet ; Ausems, Margreet G. E. M. ; Oosterwijk, Jan C. ; Peock, Susan ; Frost, Debra ; Ellis, Steve D. ; Platte, Radka ; Fineberg, Elena ; Evans, D. Gareth ; Lalloo, Fiona ; Jacobs, Chris ; Eeles, Ros ; Adlard, Julian ; Davidson, Rosemarie ; Cole, Trevor ; Cook, Jackie ; Paterson, Joan ; Douglas, Fiona ; Brewer, Carole ; Hodgson, Shirley ; Morrison, Patrick J. ; Walker, Lisa ; Rogers, Mark T. ; Donaldson, Alan ; Dorkins, Huw ; Godwin, Andrew K. ; Bove, Betsy ; Stoppa-Lyonnet, Dominique ; Houdayer, Claude ; Buecher, Bruno ; de Pauw, Antoine ; Mazoyer, Sylvie ; Calender, Alain ; Leone, Melanie ; Bressac-de Paillerets, Brigitte ; Caron, Olivier ; Sobol, Hagay ; Frenay, Marc ; Prieur, Fabienne ; Ferrer, Sandra Fert ; Mortemousque, Isabelle ; Buys, Saundra ; Daly, Mary ; Miron, Alexander ; Terry, Mary Beth ; Hopper, John L. ; John, Esther M. ; Southey, Melissa ; Goldgar, David ; Singer, Christian F. ; Fink-Retter, Anneliese ; Tea, Muy-Kheng ; Kaulich, Daphne Geschwantler ; Hansen, Thomas V. O. ; Nielsen, Finn C. ; Barkardottir, Rosa B. ; Gaudet, Mia ; Kirchhoff, Tomas ; Joseph, Vijai ; Dutra-Clarke, Ana ; Offit, Kenneth ; Piedmonte, Marion ; Kirk, Judy ; Cohn, David ; Hurteau, Jean ; Byron, John ; Fiorica, James ; Toland, Amanda E. ; Montagna, Marco ; Oliani, Cristina ; Imyanitov, Evgeny ; Isaacs, Claudine ; Tihomirova, Laima ; Blanco, Ignacio ; Lazaro, Conxi ; Teule, Alex ; Del Valle, J. ; Gayther, Simon A. ; Odunsi, Kunle ; Gross, Jenny ; Karlan, Beth Y. ; Olah, Edith ; Teo, Soo-Hwang ; Ganz, Patricia A. ; Beattie, Mary S. ; Dorfling, Cecelia M. ; van Rensburg, Elizabeth Jansen ; Diez, Orland ; Kwong, Ava ; Schmutzler, Rita K. ; Wappenschmidt, Barbara ; Engel, Christoph ; Meindl, Alfons ; Ditsch, Nina ; Arnold, Norbert ; Heidemann, Simone ; Niederacher, Dieter ; Preisler-Adams, Sabine ; Gadzicki, Dorothea ; Varon-Mateeva, Raymonda ; Deissler, Helmut ; Gehrig, Andrea ; Sutter, Christian ; Kast, Karin ; Fiebig, Britta ; Schaefer, Dieter ; Caldes, Trinidad ; de la Hoya, Miguel ; Nevanlinna, Heli ; Muranen, Taru A. ; Lesperance, Bernard ; Spurdle, Amanda B. ; Neuhausen, Susan L. ; Ding, Yuan C. ; Wang, Xianshu ; Fredericksen, Zachary ; Pankratz, Vernon S. ; Lindor, Noralane M. ; Peterlongo, Paolo ; Manoukian, Siranoush ; Peissel, Bernard ; Zaffaroni, Daniela ; Bonanni, Bernardo ; Bernard, Loris ; Dolcetti, Riccardo ; Papi, Laura ; Ottini, Laura ; Radice, Paolo ; Greene, Mark H. ; Loud, Jennifer T. ; Andrulis, Irene L. ; Ozcelik, Hilmi ; Mulligan, Anna Marie ; Glendon, Gord ; Thomassen, Mads ; Gerdes, Anne-Marie ; Jensen, Uffe B. ; Skytte, Anne-Bine ; Kruse, Torben A. ; Chenevix-Trench, Georgia ; Couch, Fergus J. ; Simard, Jacques ; Easton, Douglas F. / Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers. In: Breast Cancer Research. 2012 ; Vol. 14, No. 1.

RIS

TY - JOUR

T1 - Common variants at 12p11, 12q24, 9p21, 9q31.2 and in ZNF365 are associated with breast cancer risk for BRCA1 and/or BRCA2 mutation carriers

AU - Antoniou, Antonis C.

AU - Kuchenbaecker, Karoline B.

AU - Soucy, Penny

AU - Beesley, Jonathan

AU - Chen, Xiaoqing

AU - McGuffog, Lesley

AU - Lee, Andrew

AU - Barrowdale, Daniel

AU - Healey, Sue

AU - Sinilnikova, Olga M.

AU - Caligo, Maria A.

AU - Loman, Niklas

AU - Harbst, Katja

AU - Lindblom, Annika

AU - Arver, Brita

AU - Rosenquist, Richard

AU - Karlsson, Per

AU - Nathanson, Kate

AU - Domchek, Susan

AU - Rebbeck, Tim

AU - Jakubowska, Anna

AU - Lubinski, Jan

AU - Jaworska, Katarzyna

AU - Durda, Katarzyna

AU - Zlowowcka-Perlowska, Elzbieta

AU - Osorio, Ana

AU - Duran, Mercedes

AU - Andres, Raquel

AU - Benitez, Javier

AU - Hamann, Ute

AU - Hogervorst, Frans B.

AU - van Os, Theo A.

AU - Verhoef, Senno

AU - Meijers-Heijboer, Hanne E. J.

AU - Wijnen, Juul

AU - Garcia, Encarna B. Gomez

AU - Ligtenberg, Marjolijn J.

AU - Kriege, Mieke

AU - Collee, Margriet

AU - Ausems, Margreet G. E. M.

AU - Oosterwijk, Jan C.

AU - Peock, Susan

AU - Frost, Debra

AU - Ellis, Steve D.

AU - Platte, Radka

AU - Fineberg, Elena

AU - Evans, D. Gareth

AU - Lalloo, Fiona

AU - Jacobs, Chris

AU - Eeles, Ros

AU - Adlard, Julian

AU - Davidson, Rosemarie

AU - Cole, Trevor

AU - Cook, Jackie

AU - Paterson, Joan

AU - Douglas, Fiona

AU - Brewer, Carole

AU - Hodgson, Shirley

AU - Morrison, Patrick J.

AU - Walker, Lisa

AU - Rogers, Mark T.

AU - Donaldson, Alan

AU - Dorkins, Huw

AU - Godwin, Andrew K.

AU - Bove, Betsy

AU - Stoppa-Lyonnet, Dominique

AU - Houdayer, Claude

AU - Buecher, Bruno

AU - de Pauw, Antoine

AU - Mazoyer, Sylvie

AU - Calender, Alain

AU - Leone, Melanie

AU - Bressac-de Paillerets, Brigitte

AU - Caron, Olivier

AU - Sobol, Hagay

AU - Frenay, Marc

AU - Prieur, Fabienne

AU - Ferrer, Sandra Fert

AU - Mortemousque, Isabelle

AU - Buys, Saundra

AU - Daly, Mary

AU - Miron, Alexander

AU - Terry, Mary Beth

AU - Hopper, John L.

AU - John, Esther M.

AU - Southey, Melissa

AU - Goldgar, David

AU - Singer, Christian F.

AU - Fink-Retter, Anneliese

AU - Tea, Muy-Kheng

AU - Kaulich, Daphne Geschwantler

AU - Hansen, Thomas V. O.

AU - Nielsen, Finn C.

AU - Barkardottir, Rosa B.

AU - Gaudet, Mia

AU - Kirchhoff, Tomas

AU - Joseph, Vijai

AU - Dutra-Clarke, Ana

AU - Offit, Kenneth

AU - Piedmonte, Marion

AU - Kirk, Judy

AU - Cohn, David

AU - Hurteau, Jean

AU - Byron, John

AU - Fiorica, James

AU - Toland, Amanda E.

AU - Montagna, Marco

AU - Oliani, Cristina

AU - Imyanitov, Evgeny

AU - Isaacs, Claudine

AU - Tihomirova, Laima

AU - Blanco, Ignacio

AU - Lazaro, Conxi

AU - Teule, Alex

AU - Del Valle, J.

AU - Gayther, Simon A.

AU - Odunsi, Kunle

AU - Gross, Jenny

AU - Karlan, Beth Y.

AU - Olah, Edith

AU - Teo, Soo-Hwang

AU - Ganz, Patricia A.

AU - Beattie, Mary S.

AU - Dorfling, Cecelia M.

AU - van Rensburg, Elizabeth Jansen

AU - Diez, Orland

AU - Kwong, Ava

AU - Schmutzler, Rita K.

AU - Wappenschmidt, Barbara

AU - Engel, Christoph

AU - Meindl, Alfons

AU - Ditsch, Nina

AU - Arnold, Norbert

AU - Heidemann, Simone

AU - Niederacher, Dieter

AU - Preisler-Adams, Sabine

AU - Gadzicki, Dorothea

AU - Varon-Mateeva, Raymonda

AU - Deissler, Helmut

AU - Gehrig, Andrea

AU - Sutter, Christian

AU - Kast, Karin

AU - Fiebig, Britta

AU - Schaefer, Dieter

AU - Caldes, Trinidad

AU - de la Hoya, Miguel

AU - Nevanlinna, Heli

AU - Muranen, Taru A.

AU - Lesperance, Bernard

AU - Spurdle, Amanda B.

AU - Neuhausen, Susan L.

AU - Ding, Yuan C.

AU - Wang, Xianshu

AU - Fredericksen, Zachary

AU - Pankratz, Vernon S.

AU - Lindor, Noralane M.

AU - Peterlongo, Paolo

AU - Manoukian, Siranoush

AU - Peissel, Bernard

AU - Zaffaroni, Daniela

AU - Bonanni, Bernardo

AU - Bernard, Loris

AU - Dolcetti, Riccardo

AU - Papi, Laura

AU - Ottini, Laura

AU - Radice, Paolo

AU - Greene, Mark H.

AU - Loud, Jennifer T.

AU - Andrulis, Irene L.

AU - Ozcelik, Hilmi

AU - Mulligan, Anna Marie

AU - Glendon, Gord

AU - Thomassen, Mads

AU - Gerdes, Anne-Marie

AU - Jensen, Uffe B.

AU - Skytte, Anne-Bine

AU - Kruse, Torben A.

AU - Chenevix-Trench, Georgia

AU - Couch, Fergus J.

AU - Simard, Jacques

AU - Easton, Douglas F.

PY - 2012

Y1 - 2012

N2 - Introduction: Several common alleles have been shown to be associated with breast and/or ovarian cancer risk for BRCA1 and BRCA2 mutation carriers. Recent genome-wide association studies of breast cancer have identified eight additional breast cancer susceptibility loci: rs1011970 (9p21, CDKN2A/B), rs10995190 (ZNF365), rs704010 (ZMIZ1), rs2380205 (10p15), rs614367 (11q13), rs1292011 (12q24), rs10771399 (12p11 near PTHLH) and rs865686 (9q31.2). Methods: To evaluate whether these single nucleotide polymorphisms (SNPs) are associated with breast cancer risk for BRCA1 and BRCA2 carriers, we genotyped these SNPs in 12,599 BRCA1 and 7,132 BRCA2 mutation carriers and analysed the associations with breast cancer risk within a retrospective likelihood framework. Results: Only SNP rs10771399 near PTHLH was associated with breast cancer risk for BRCA1 mutation carriers (per-allele hazard ratio (HR) = 0.87, 95% CI: 0.81 to 0.94, P-trend = 3 x 10(-4)). The association was restricted to mutations proven or predicted to lead to absence of protein expression (HR = 0.82, 95% CI: 0.74 to 0.90, P-trend = 3.1 x 10(-5), P-difference = 0.03). Four SNPs were associated with the risk of breast cancer for BRCA2 mutation carriers: rs10995190, P-trend = 0.015; rs1011970, P-trend = 0.048; rs865686, 2df P = 0.007; rs1292011 2df P = 0.03. rs10771399 (PTHLH) was predominantly associated with estrogen receptor (ER)-negative breast cancer for BRCA1 mutation carriers (HR = 0.81, 95% CI: 0.74 to 0.90, P-trend = 4 x 10(-5)) and there was marginal evidence of association with ER- negative breast cancer for BRCA2 mutation carriers (HR = 0.78, 95% CI: 0.62 to 1.00, P-trend = 0.049). Conclusions: The present findings, in combination with previously identified modifiers of risk, will ultimately lead to more accurate risk prediction and an improved understanding of the disease etiology in BRCA1 and BRCA2 mutation carriers.

AB - Introduction: Several common alleles have been shown to be associated with breast and/or ovarian cancer risk for BRCA1 and BRCA2 mutation carriers. Recent genome-wide association studies of breast cancer have identified eight additional breast cancer susceptibility loci: rs1011970 (9p21, CDKN2A/B), rs10995190 (ZNF365), rs704010 (ZMIZ1), rs2380205 (10p15), rs614367 (11q13), rs1292011 (12q24), rs10771399 (12p11 near PTHLH) and rs865686 (9q31.2). Methods: To evaluate whether these single nucleotide polymorphisms (SNPs) are associated with breast cancer risk for BRCA1 and BRCA2 carriers, we genotyped these SNPs in 12,599 BRCA1 and 7,132 BRCA2 mutation carriers and analysed the associations with breast cancer risk within a retrospective likelihood framework. Results: Only SNP rs10771399 near PTHLH was associated with breast cancer risk for BRCA1 mutation carriers (per-allele hazard ratio (HR) = 0.87, 95% CI: 0.81 to 0.94, P-trend = 3 x 10(-4)). The association was restricted to mutations proven or predicted to lead to absence of protein expression (HR = 0.82, 95% CI: 0.74 to 0.90, P-trend = 3.1 x 10(-5), P-difference = 0.03). Four SNPs were associated with the risk of breast cancer for BRCA2 mutation carriers: rs10995190, P-trend = 0.015; rs1011970, P-trend = 0.048; rs865686, 2df P = 0.007; rs1292011 2df P = 0.03. rs10771399 (PTHLH) was predominantly associated with estrogen receptor (ER)-negative breast cancer for BRCA1 mutation carriers (HR = 0.81, 95% CI: 0.74 to 0.90, P-trend = 4 x 10(-5)) and there was marginal evidence of association with ER- negative breast cancer for BRCA2 mutation carriers (HR = 0.78, 95% CI: 0.62 to 1.00, P-trend = 0.049). Conclusions: The present findings, in combination with previously identified modifiers of risk, will ultimately lead to more accurate risk prediction and an improved understanding of the disease etiology in BRCA1 and BRCA2 mutation carriers.

U2 - 10.1186/bcr3121

DO - 10.1186/bcr3121

M3 - Article

C2 - 22348646

VL - 14

JO - Breast Cancer Research

JF - Breast Cancer Research

SN - 1465-5411

IS - 1

ER -