Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk

Research output: Contribution to journalArticle

Abstract

To identify new risk variants for chronic lymphocytic leukemia (CLL), we conducted a genome-wide association study of 299,983 tagging SNPs, with validation in four additional series totaling 2,503 cases and 5,789 controls. We identified four new risk loci for CLL at 2q37.3 (rs757978, FARP2; odds ratio (OR) = 1.39; P = 2.11 x 10(-9)), 8q24.21 (rs2456449; OR = 1.26; P = 7.84 x 10(-10)), 15q21.3 (rs7169431; OR = 1.36; P = 4.74 x 10(-7)) and 16q24.1 (rs305061; OR = 1.22; P = 3.60 x 10(-7)). We also found evidence for risk loci at 15q25.2 (rs783540, CPEB1; OR = 1.18; P = 3.67 x 10(-6)) and 18q21.1 (rs1036935; OR = 1.22; P = 2.28 x 10(-6)). These data provide further evidence for genetic susceptibility to this B-cell hematological malignancy.

Details

Authors
  • Dalemari Crowther-Swanepoel
  • Peter Broderick
  • Maria Chiara Di Bernardo
  • Sara E. Dobbins
  • Maria Torres
  • Mahmoud Mansouri
  • Clara Ruiz-Ponte
  • Anna Enjuanes
  • Richard Rosenquist
  • Angel Carracedo
  • Jesper Jurlander
  • Elias Campo
  • Emilio Montserrat
  • Karin E. Smedby
  • Martin J. S. Dyer
  • Estella Matutes
  • Claire Dearden
  • Nicola J. Sunter
  • Andrew G. Hall
  • Tryfonia Mainou-Fowler
  • Graham H. Jackson
  • Geoffrey Summerfield
  • Robert J. Harris
  • Andrew R. Pettitt
  • David J. Allsup
  • James R. Bailey
  • Guy Pratt
  • Chris Pepper
  • Chris Fegan
  • Anton Parker
  • David Oscier
  • James M. Allan
  • Daniel Catovsky
  • Richard S. Houlston
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Hematology
Original languageEnglish
Pages (from-to)132-U59
JournalNature Genetics
Volume42
Issue number2
Publication statusPublished - 2010
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Hematology/Transplantation (013022014)