Complement deficiency states and associated infections.

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Complement deficiency states and associated infections. / Melander Skattum, Lillemor; van Deuren, Marcel; van der Poll, Tom; Truedsson, Lennart.

In: Molecular Immunology, Vol. 48, 2011, p. 1643-1655.

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Melander Skattum, Lillemor ; van Deuren, Marcel ; van der Poll, Tom ; Truedsson, Lennart. / Complement deficiency states and associated infections. In: Molecular Immunology. 2011 ; Vol. 48. pp. 1643-1655.

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TY - JOUR

T1 - Complement deficiency states and associated infections.

AU - Melander Skattum, Lillemor

AU - van Deuren, Marcel

AU - van der Poll, Tom

AU - Truedsson, Lennart

PY - 2011

Y1 - 2011

N2 - A major function of the immune system is to protect the host from microbial infections. The complement system plays important roles in both the innate and the adaptive immune defense and also acts as a bridge between these arms of immunity. This is obvious from complement deficiencies which in varying degree, depending on which factor is missing, are associated with increased infection susceptibility and also increased risk for other, mainly autoimmune diseases. Genetically determined deficiencies are described for almost all complement proteins but the consequences show a wide variation. Here the genetic defects and molecular abnormalities in complement deficient persons, related clinically relevant infections and the options for prevention and therapy are reviewed. The roles of complement in host defense against common infections are also discussed.

AB - A major function of the immune system is to protect the host from microbial infections. The complement system plays important roles in both the innate and the adaptive immune defense and also acts as a bridge between these arms of immunity. This is obvious from complement deficiencies which in varying degree, depending on which factor is missing, are associated with increased infection susceptibility and also increased risk for other, mainly autoimmune diseases. Genetically determined deficiencies are described for almost all complement proteins but the consequences show a wide variation. Here the genetic defects and molecular abnormalities in complement deficient persons, related clinically relevant infections and the options for prevention and therapy are reviewed. The roles of complement in host defense against common infections are also discussed.

U2 - 10.1016/j.molimm.2011.05.001

DO - 10.1016/j.molimm.2011.05.001

M3 - Article

VL - 48

SP - 1643

EP - 1655

JO - Immunochemistry

T2 - Immunochemistry

JF - Immunochemistry

SN - 1872-9142

ER -