Completion dissection or observation for sentinel-node metastasis in melanoma

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Completion dissection or observation for sentinel-node metastasis in melanoma. / Faries, B.; Thompson, J. F.; Cochran, Alistair J.; Andtbacka, R. H.; Mozzillo, Nicola; Zager, J. S.; Jahkola, Tiina; Bowles, T. L.; Testori, A; Beitsch, P. D.; Hoekstra, H J; Moncrieff, M.; Ingvar, C.; Wouters, M. W. J. M.; Sabel, M. S.; Levine, E. A.; Agnese, D.; Henderson, M; Dummer, R.; Rossi-Alvarez, C; Neves, R. I.; Trocha, S. D.; Wright, Alan F; Byrd, D. R.; Matter, M.; Hsueh, E.; MacKenzie-Ross, A.; Johnson, D. B.; Terheyden, P.; Berger, A. C.; Huston, T. L.; Wayne, J. D.; Smithers, B. M.; Neuman, H. B.; Schneebaum, S.; Gershenwald, Jeffrey E; Ariyan, C. E.; Desai, D. C.; Jacobs, L. L.; McMasters, K. M.; Gesierich, A.; Hersey, P; Bines, S. D.; Kane, J. M.; Barth, R. J.; McKinnon, G.; Farma, J. M.; Schultz, E.; Vidal-Sicart, Sergi; Hoefer, R. A.; Lewis, Melanie J.; Scheri, R.; Kelley, M. C.; Nieweg, Omgo E.; Noyes, R. D.; Hoon, Dave S. B.; Wang, H. J.; Elashoff, D. A.; Elashoff, R. M.

In: New England Journal of Medicine, Vol. 376, No. 23, 08.06.2017, p. 2211-2222.

Research output: Contribution to journalArticle

Harvard

Faries, B, Thompson, JF, Cochran, AJ, Andtbacka, RH, Mozzillo, N, Zager, JS, Jahkola, T, Bowles, TL, Testori, A, Beitsch, PD, Hoekstra, HJ, Moncrieff, M, Ingvar, C, Wouters, MWJM, Sabel, MS, Levine, EA, Agnese, D, Henderson, M, Dummer, R, Rossi-Alvarez, C, Neves, RI, Trocha, SD, Wright, AF, Byrd, DR, Matter, M, Hsueh, E, MacKenzie-Ross, A, Johnson, DB, Terheyden, P, Berger, AC, Huston, TL, Wayne, JD, Smithers, BM, Neuman, HB, Schneebaum, S, Gershenwald, JE, Ariyan, CE, Desai, DC, Jacobs, LL, McMasters, KM, Gesierich, A, Hersey, P, Bines, SD, Kane, JM, Barth, RJ, McKinnon, G, Farma, JM, Schultz, E, Vidal-Sicart, S, Hoefer, RA, Lewis, MJ, Scheri, R, Kelley, MC, Nieweg, OE, Noyes, RD, Hoon, DSB, Wang, HJ, Elashoff, DA & Elashoff, RM 2017, 'Completion dissection or observation for sentinel-node metastasis in melanoma', New England Journal of Medicine, vol. 376, no. 23, pp. 2211-2222. https://doi.org/10.1056/NEJMoa1613210

APA

Faries, B., Thompson, J. F., Cochran, A. J., Andtbacka, R. H., Mozzillo, N., Zager, J. S., Jahkola, T., Bowles, T. L., Testori, A., Beitsch, P. D., Hoekstra, H. J., Moncrieff, M., Ingvar, C., Wouters, M. W. J. M., Sabel, M. S., Levine, E. A., Agnese, D., Henderson, M., Dummer, R., ... Elashoff, R. M. (2017). Completion dissection or observation for sentinel-node metastasis in melanoma. New England Journal of Medicine, 376(23), 2211-2222. https://doi.org/10.1056/NEJMoa1613210

CBE

Faries B, Thompson JF, Cochran AJ, Andtbacka RH, Mozzillo N, Zager JS, Jahkola T, Bowles TL, Testori A, Beitsch PD, Hoekstra HJ, Moncrieff M, Ingvar C, Wouters MWJM, Sabel MS, Levine EA, Agnese D, Henderson M, Dummer R, Rossi-Alvarez C, Neves RI, Trocha SD, Wright AF, Byrd DR, Matter M, Hsueh E, MacKenzie-Ross A, Johnson DB, Terheyden P, Berger AC, Huston TL, Wayne JD, Smithers BM, Neuman HB, Schneebaum S, Gershenwald JE, Ariyan CE, Desai DC, Jacobs LL, McMasters KM, Gesierich A, Hersey P, Bines SD, Kane JM, Barth RJ, McKinnon G, Farma JM, Schultz E, Vidal-Sicart S, Hoefer RA, Lewis MJ, Scheri R, Kelley MC, Nieweg OE, Noyes RD, Hoon DSB, Wang HJ, Elashoff DA, Elashoff RM. 2017. Completion dissection or observation for sentinel-node metastasis in melanoma. New England Journal of Medicine. 376(23):2211-2222. https://doi.org/10.1056/NEJMoa1613210

MLA

Vancouver

Faries B, Thompson JF, Cochran AJ, Andtbacka RH, Mozzillo N, Zager JS et al. Completion dissection or observation for sentinel-node metastasis in melanoma. New England Journal of Medicine. 2017 Jun 8;376(23):2211-2222. https://doi.org/10.1056/NEJMoa1613210

Author

Faries, B. ; Thompson, J. F. ; Cochran, Alistair J. ; Andtbacka, R. H. ; Mozzillo, Nicola ; Zager, J. S. ; Jahkola, Tiina ; Bowles, T. L. ; Testori, A ; Beitsch, P. D. ; Hoekstra, H J ; Moncrieff, M. ; Ingvar, C. ; Wouters, M. W. J. M. ; Sabel, M. S. ; Levine, E. A. ; Agnese, D. ; Henderson, M ; Dummer, R. ; Rossi-Alvarez, C ; Neves, R. I. ; Trocha, S. D. ; Wright, Alan F ; Byrd, D. R. ; Matter, M. ; Hsueh, E. ; MacKenzie-Ross, A. ; Johnson, D. B. ; Terheyden, P. ; Berger, A. C. ; Huston, T. L. ; Wayne, J. D. ; Smithers, B. M. ; Neuman, H. B. ; Schneebaum, S. ; Gershenwald, Jeffrey E ; Ariyan, C. E. ; Desai, D. C. ; Jacobs, L. L. ; McMasters, K. M. ; Gesierich, A. ; Hersey, P ; Bines, S. D. ; Kane, J. M. ; Barth, R. J. ; McKinnon, G. ; Farma, J. M. ; Schultz, E. ; Vidal-Sicart, Sergi ; Hoefer, R. A. ; Lewis, Melanie J. ; Scheri, R. ; Kelley, M. C. ; Nieweg, Omgo E. ; Noyes, R. D. ; Hoon, Dave S. B. ; Wang, H. J. ; Elashoff, D. A. ; Elashoff, R. M. / Completion dissection or observation for sentinel-node metastasis in melanoma. In: New England Journal of Medicine. 2017 ; Vol. 376, No. 23. pp. 2211-2222.

RIS

TY - JOUR

T1 - Completion dissection or observation for sentinel-node metastasis in melanoma

AU - Faries, B.

AU - Thompson, J. F.

AU - Cochran, Alistair J.

AU - Andtbacka, R. H.

AU - Mozzillo, Nicola

AU - Zager, J. S.

AU - Jahkola, Tiina

AU - Bowles, T. L.

AU - Testori, A

AU - Beitsch, P. D.

AU - Hoekstra, H J

AU - Moncrieff, M.

AU - Ingvar, C.

AU - Wouters, M. W. J. M.

AU - Sabel, M. S.

AU - Levine, E. A.

AU - Agnese, D.

AU - Henderson, M

AU - Dummer, R.

AU - Rossi-Alvarez, C

AU - Neves, R. I.

AU - Trocha, S. D.

AU - Wright, Alan F

AU - Byrd, D. R.

AU - Matter, M.

AU - Hsueh, E.

AU - MacKenzie-Ross, A.

AU - Johnson, D. B.

AU - Terheyden, P.

AU - Berger, A. C.

AU - Huston, T. L.

AU - Wayne, J. D.

AU - Smithers, B. M.

AU - Neuman, H. B.

AU - Schneebaum, S.

AU - Gershenwald, Jeffrey E

AU - Ariyan, C. E.

AU - Desai, D. C.

AU - Jacobs, L. L.

AU - McMasters, K. M.

AU - Gesierich, A.

AU - Hersey, P

AU - Bines, S. D.

AU - Kane, J. M.

AU - Barth, R. J.

AU - McKinnon, G.

AU - Farma, J. M.

AU - Schultz, E.

AU - Vidal-Sicart, Sergi

AU - Hoefer, R. A.

AU - Lewis, Melanie J.

AU - Scheri, R.

AU - Kelley, M. C.

AU - Nieweg, Omgo E.

AU - Noyes, R. D.

AU - Hoon, Dave S. B.

AU - Wang, H. J.

AU - Elashoff, D. A.

AU - Elashoff, R. M.

PY - 2017/6/8

Y1 - 2017/6/8

N2 - BACKGROUND Sentinel-lymph-node biopsy is associated with increased melanoma-specific survival (i.e., survival until death from melanoma) among patients with node-positive intermediatethickness melanomas (1.2 to 3.5 mm). The value of completion lymph-node dissection for patients with sentinel-node metastases is not clear. METHODS In an international trial, we randomly assigned patients with sentinel-node metastases detected by means of standard pathological assessment or a multimarker molecular assay to immediate completion lymph-node dissection (dissection group) or nodal observation with ultrasonography (observation group). The primary end point was melanoma-specific survival. Secondary end points included disease-free survival and the cumulative rate of nonsentinel-node metastasis. RESULTS Immediate completion lymph-node dissection was not associated with increased melanomaspecific survival among 1934 patients with data that could be evaluated in an intention-Totreat analysis or among 1755 patients in the per-protocol analysis. In the per-protocol analysis, the mean (-SE) 3-year rate of melanoma-specific survival was similar in the dissection group and the observation group (86-1.3% and 86-1.2%, respectively; P = 0.42 by the logrank test) at a median follow-up of 43 months. The rate of disease-free survival was slightly higher in the dissection group than in the observation group (68-1.7% and 63-1.7%, respectively; P = 0.05 by the log-rank test) at 3 years, based on an increased rate of disease control in the regional nodes at 3 years (92-1.0% vs. 77-1.5%; P<0.001 by the log-rank test); these results must be interpreted with caution. Nonsentinel-node metastases, identified in 11.5% of the patients in the dissection group, were a strong, independent prognostic factor for recurrence (hazard ratio, 1.78; P = 0.005). Lymphedema was observed in 24.1% of the patients in the dissection group and in 6.3% of those in the observation group. CONCLUSIONS Immediate completion lymph-node dissection increased the rate of regional disease control and provided prognostic information but did not increase melanoma-specific survival among patients with melanoma and sentinel-node metastases.

AB - BACKGROUND Sentinel-lymph-node biopsy is associated with increased melanoma-specific survival (i.e., survival until death from melanoma) among patients with node-positive intermediatethickness melanomas (1.2 to 3.5 mm). The value of completion lymph-node dissection for patients with sentinel-node metastases is not clear. METHODS In an international trial, we randomly assigned patients with sentinel-node metastases detected by means of standard pathological assessment or a multimarker molecular assay to immediate completion lymph-node dissection (dissection group) or nodal observation with ultrasonography (observation group). The primary end point was melanoma-specific survival. Secondary end points included disease-free survival and the cumulative rate of nonsentinel-node metastasis. RESULTS Immediate completion lymph-node dissection was not associated with increased melanomaspecific survival among 1934 patients with data that could be evaluated in an intention-Totreat analysis or among 1755 patients in the per-protocol analysis. In the per-protocol analysis, the mean (-SE) 3-year rate of melanoma-specific survival was similar in the dissection group and the observation group (86-1.3% and 86-1.2%, respectively; P = 0.42 by the logrank test) at a median follow-up of 43 months. The rate of disease-free survival was slightly higher in the dissection group than in the observation group (68-1.7% and 63-1.7%, respectively; P = 0.05 by the log-rank test) at 3 years, based on an increased rate of disease control in the regional nodes at 3 years (92-1.0% vs. 77-1.5%; P<0.001 by the log-rank test); these results must be interpreted with caution. Nonsentinel-node metastases, identified in 11.5% of the patients in the dissection group, were a strong, independent prognostic factor for recurrence (hazard ratio, 1.78; P = 0.005). Lymphedema was observed in 24.1% of the patients in the dissection group and in 6.3% of those in the observation group. CONCLUSIONS Immediate completion lymph-node dissection increased the rate of regional disease control and provided prognostic information but did not increase melanoma-specific survival among patients with melanoma and sentinel-node metastases.

UR - http://www.scopus.com/inward/record.url?scp=85020241826&partnerID=8YFLogxK

U2 - 10.1056/NEJMoa1613210

DO - 10.1056/NEJMoa1613210

M3 - Article

C2 - 28591523

AN - SCOPUS:85020241826

VL - 376

SP - 2211

EP - 2222

JO - New England Journal of Medicine

JF - New England Journal of Medicine

SN - 0028-4793

IS - 23

ER -