Computerized cognition assessment during acetylcholinesterase inhibitor treatment in Alzheimer's disease

Research output: Contribution to journalArticle

Abstract

Objectives - Alzheimer's disease assessment scale-cognitive subscale (ADAS-Cog) has become a standard clinical trials outcome for cognition, but has been recognized as deficient in areas including coverage of cognitive domains, sensitivity and standardization. Computerized test batteries may address some of these issues. The cognitive drug research computerized assessment (CDR) system is validated in Alzheimer's disease (AD). This study was designed to further evaluate validity in relation to ADAS-Cog, mini mental state examination (MMSE) and cerebrospinal fluid (CSF) biomarkers and psychometric properties, in a population of Alzheimer's patients on stable anticholinesterase treatment. Materials and methods - Patients completed cognition assessments, CSF and blood sampling at baseline and 6 months later. Data for 65 patients were evaluated. Results - The CDR system demonstrated good psychometric properties in this population. Measures of psychomotor speed showed possible sensitivity to decline over 6 months. Conclusions - There are a number of methodological problems with current cognition assessment methodology for clinical trials. Computerized measures and in particular millisecond reaction time measures, may address many of these issues.

Details

Authors
  • K. Wesnes
  • C. Edgar
  • N. Andreasen
  • P. Annas
  • H. Basun
  • L. Lannfelt
  • H. Zetterberg
  • K. Blennow
  • Lennart Minthon
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurology

Keywords

  • Alzheimer's disease assessment scale-cognitive subscale, system, cognitive drug research, computerized, cognition, Alzheimer's disease, mini, mental state examination
Original languageEnglish
Pages (from-to)270-277
JournalActa Neurologica Scandinavica
Volume122
Issue number4
Publication statusPublished - 2010
Publication categoryResearch
Peer-reviewedYes