Confirmation of the Intracoronary Near-Infrared Spectroscopy Threshold of Lipid-Rich Plaques That Underlie ST-Segment-Elevation Myocardial Infarction.

Research output: Contribution to journalArticle


In a previous exploratory analysis, intracoronary near-infrared spectroscopy (NIRS) found the majority of culprit lesions in ST-segment-elevation myocardial infarction (STEMI) to contain a maximum lipid core burden index in 4 mm (maxLCBI4mm) of >400. This initial study was limited by a small sample size, enrollment at a single center, and post hoc selection of the maxLCBI4mm ≥400 threshold. This study was designed a priori to substantiate the ability of NIRS to discriminate STEMI culprit from nonculprit segments and to confirm the performance of the maxLCBI4mm ≥400 threshold.


  • Ryan D Madder
  • Rishi Puri
  • James E Muller
  • Jan Harnek
  • Matthias Götberg
  • Stacie VanOosterhout
  • Margaret Chi
  • David Wohns
  • Richard McNamara
  • Kathy Wolski
  • Sean Madden
  • Samuel Sidharta
  • Jordan Andrews
  • Stephen J Nicholls
  • David Erlinge
External organisations
  • Spectrum Health System
  • Cleveland Clinic Foundation
  • Infraredx Inc
  • University of Adelaide
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cardiac and Cardiovascular Systems
  • Radiology, Nuclear Medicine and Medical Imaging
Original languageEnglish
Pages (from-to)1010-1015
JournalArteriosclerosis, Thrombosis and Vascular Biology
Issue number5
Early online date2016 Mar 3
Publication statusPublished - 2016
Publication categoryResearch