Connective tissue growth factor expression and Smad signaling during mouse heart development and myocardial infarction

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Abstract

Connective tissue growth factor (CTGF) is reported to be a target gene of transforming growth factor beta (TGFbeta) and bone morphogenetic protein (BMP) in vitro. Its physiological role in angiogenesis and skeletogenesis during mouse development has been described recently. Here, we have mapped expression of CTGF mRNA during mouse heart development, postnatal adult life, and after experimental myocardial infarction. Furthermore, we investigated the relationship between CTGF and the BMP/TGFbeta signaling pathway in particular during heart development in mutant mice. Postnatally, CTGF expression in the heart became restricted to the atrium. Strikingly, 1 week after myocardial infarction, when myocytes have disappeared from the infarct zone, CTGF and TGFbeta expression as well as activated forms of TGFbeta but not BMP, Smad effector proteins are colocalized exclusively in the fibroblasts of the scar tissue, suggesting possible cooperation between CTGF and TGFbeta, during the pathological fibrotic response. (C) 2004 Wiley-Liss, Inc.

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Authors
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Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Hematology

Keywords

  • myocardial infarction, heart development, mouse, TGF beta, CTGF
Original languageEnglish
Pages (from-to)542-550
JournalDevelopmental Dynamics
Volume231
Issue number3
Publication statusPublished - 2004
Publication categoryResearch
Peer-reviewedYes