Construction of polyamine-modified uridine and adenosine derivatives-evaluation of DNA binding capacity and cytotoxicity in vitro

Research output: Contribution to journalArticle

Abstract

We here report the synthesis of the two polyamine-based nucleoside derivatives 5-{[bis-(3-aminopropyl)amino]acetamido-1-propynyl}uridine and 2-{[bis-(3-aminopropyl)amino]-acetamido-1-propynyl}adenosine. The various polyamine derivatives have been used in thermal melting analysis using DNA from herring testes, and in cellular studies using four different cell lines. The compounds were all found to be non-toxic, thus holding good promise for future use as siRNA building blocks.

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Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Zoology

Keywords

  • Modified nucleoside, Adenosine, Uridine, Polyamine derivatives
Original languageEnglish
Pages (from-to)7426-7433
JournalBioorganic & Medicinal Chemistry
Volume15
Issue number23
Publication statusPublished - 2007
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Functional Zoology (432112239), Biochemistry and Structural Biology (S) (000006142), Department of Biology (000016100), Organic chemistry (S/LTH) (011001240)