Contact dermatitis caused by glucose sensors—15 adult patients tested with a medical device patch test series

Research output: Contribution to journalArticle

Abstract

Background: Several cases of allergic contact dermatitis (ACD) to the glucose sensor FreeStyle Libre have been reported. Isobornyl acrylate (IBOA) and N,N-dimethylacrylamide (DMAA) are known culprit allergens. Objectives: To evaluate patients with suspected ACD to FreeStyle Libre in a standardized manner, present causative allergens, and assess patient-reported implications. Methods: A total of 15 patients with suspected ACD to FreeStyle Libre were patch tested with the Swedish baseline series and a new medical device series. IBOA and DMAA were tested at 0.1% and 0.3% in petrolatum (pet.). Readings were performed on day (D) 3 and D7. Background data, details on skin reactions, and associated implications were assessed using a questionnaire. Results: Thirteen patients were sensitized to IBOA and four to DMAA. Two positive reactions to IBOA and one to DMAA were seen only at 0.3% concentration on D7. Median duration of sensor use before dermatitis onset was 6 months. Half the number of the patients took precautions in everyday life due to sensor-related skin reactions. Six patients discontinued sensor usage. Conclusions: Patients with suspected ACD to glucose sensors should be evaluated with a relevant patch test series containing IBOA and DMAA. Adding the 0.3% pet. concentration is recommended. The reading on D7 is necessary.

Details

Authors
Organisations
External organisations
  • Blekinge Hospital
  • Skåne University Hospital
  • Mahidol University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Dermatology and Venereal Diseases

Keywords

  • adhesive, allergic contact dermatitis, diabetes mellitus, FreeStyle Libre, glucose sensor, isobornyl acrylate, medical device, N,N-dimethylacrylamide
Original languageEnglish
Pages (from-to)301-309
Number of pages9
JournalContact Dermatitis
Volume83
Issue number4
Publication statusPublished - 2020 Oct 1
Publication categoryResearch
Peer-reviewedYes