Content of adenosine 3′:5′-cyclic monophosphate in the pancreatic islets of mice with a hereditary defect of insulin secretion

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Glucose (20 mM) released insulin from pancreatic islets of C57BL 6J- db2J db2J mice, the response being potentiated by 1 mM 3-isobutyl-1-methylxanthine. Islets of C57BL KsJ- db db mice failed to respond to glucose and released only little insulin when challenged with both glucose and methylxanthine. After incubation with 0 or 20 mM glucose alone the islet content of adenosine 3′:5′-cyclic monophosphate did not differ between the two types of mice or between glucose concentrations. 3-Isobutyl-1-methylxanthine increased the islet adenosine 3′:5′-cyclic monophosphate markedly in 6J- db2J db2J mice but not significantly in KsJ- db db mice.


External organisations
  • Umeå University
Original languageEnglish
Pages (from-to)1391-1396
Number of pages6
JournalBiochemical and Biophysical Research Communications
Issue number4
Publication statusPublished - 1974 Oct 23
Publication categoryResearch
Externally publishedYes