Continuous dopaminergic stimulation therapy for Parkinson's disease - Recent advances

Research output: Contribution to journalArticle

Abstract

Purpose of review We aim to review the most interesting recent advances on the clinical aspects of continuous dopaminergic stimulation in Parkinson's disease. Recent findings Several large, open-label studies have presented data that are in line with the randomized controlled trial on L-dopa-carbidopa intestinal gel infusion, which shows that a continuous drug delivery can improve motor fluctuations and dyskinesia in patients with advanced Parkinson's disease. Furthermore, new extended-release formulations of L-dopa aim to stabilize plasma concentrations and thus reduce the degree of motor complications - despite a reduced number of daily doses. Transdermal rotigotine has been shown to be effective for specific subgroups of patients, although the general effect on nonmotor symptoms is still unclear. New products for L-dopa infusion are also at different stages of development, but the routes of administration are widely different: intrajejunal, subcutaneous, and oral. Summary The understanding of the mechanisms behind the complications of long-term L-dopa treatment is still not complete, but therapies aiming for continuous dopaminergic stimulation are already widely used in clinical practice and the evidence strength is improving. However, there is still an urgent need for both less invasive and less costly options in order to increase access to these therapies.

Details

Authors
Organisations
External organisations
  • Skåne University Hospital
  • Central Hospital Bremerhaven
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Pharmacology and Toxicology
  • Neurology

Keywords

  • antiparkinson agents, continuous dopaminergic stimulation, continuous drug delivery, drugs, investigational, Parkinson's disease
Original languageEnglish
Pages (from-to)474-479
Number of pages6
JournalCurrent Opinion in Neurology
Volume29
Issue number4
Publication statusPublished - 2016 Aug 1
Publication categoryResearch
Peer-reviewedYes