Contribution of Antibody-based Protein Profiling to the Human Chromosome-centric Proteome Project (C-HPP)

Research output: Contribution to journalArticle

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Contribution of Antibody-based Protein Profiling to the Human Chromosome-centric Proteome Project (C-HPP). / Fagerberg, Linn; Oksvold, Per; Skogs, Marie; Algenas, Cajsa; Lundberg, Emma; Ponten, Fredrik; Sivertsson, Asa; Odeberg, Jacob; Klevebring, Daniel; Kampf, Caroline; Asplund, Anna; Sjostedt, Evelina; Szigyarto, Cristina Al-Khalili; Edqvist, Per-Henrik; Olsson, IngMarie; Rydberg, Urban; Hudson, Paul; Takanen, Jenny Ottosson; Berling, Holger; Bjorling, Lisa; Tegel, Hanna; Rockberg, Johan; Nilsson, Peter; Navani, Sanjay; Jirström, Karin; Mulder, Jan; Schwenk, Jochen M.; Zwahlen, Martin; Hober, Sophia; Forsberg, Mattias; von Feilitzen, Kalle; Uhlen, Mathias.

In: Journal of Proteome Research, Vol. 12, No. 6, 2013, p. 2439-2448.

Research output: Contribution to journalArticle

Harvard

Fagerberg, L, Oksvold, P, Skogs, M, Algenas, C, Lundberg, E, Ponten, F, Sivertsson, A, Odeberg, J, Klevebring, D, Kampf, C, Asplund, A, Sjostedt, E, Szigyarto, CA-K, Edqvist, P-H, Olsson, I, Rydberg, U, Hudson, P, Takanen, JO, Berling, H, Bjorling, L, Tegel, H, Rockberg, J, Nilsson, P, Navani, S, Jirström, K, Mulder, J, Schwenk, JM, Zwahlen, M, Hober, S, Forsberg, M, von Feilitzen, K & Uhlen, M 2013, 'Contribution of Antibody-based Protein Profiling to the Human Chromosome-centric Proteome Project (C-HPP)', Journal of Proteome Research, vol. 12, no. 6, pp. 2439-2448. https://doi.org/10.1021/pr300924j

APA

Fagerberg, L., Oksvold, P., Skogs, M., Algenas, C., Lundberg, E., Ponten, F., Sivertsson, A., Odeberg, J., Klevebring, D., Kampf, C., Asplund, A., Sjostedt, E., Szigyarto, C. A-K., Edqvist, P-H., Olsson, I., Rydberg, U., Hudson, P., Takanen, J. O., Berling, H., ... Uhlen, M. (2013). Contribution of Antibody-based Protein Profiling to the Human Chromosome-centric Proteome Project (C-HPP). Journal of Proteome Research, 12(6), 2439-2448. https://doi.org/10.1021/pr300924j

CBE

Fagerberg L, Oksvold P, Skogs M, Algenas C, Lundberg E, Ponten F, Sivertsson A, Odeberg J, Klevebring D, Kampf C, Asplund A, Sjostedt E, Szigyarto CA-K, Edqvist P-H, Olsson I, Rydberg U, Hudson P, Takanen JO, Berling H, Bjorling L, Tegel H, Rockberg J, Nilsson P, Navani S, Jirström K, Mulder J, Schwenk JM, Zwahlen M, Hober S, Forsberg M, von Feilitzen K, Uhlen M. 2013. Contribution of Antibody-based Protein Profiling to the Human Chromosome-centric Proteome Project (C-HPP). Journal of Proteome Research. 12(6):2439-2448. https://doi.org/10.1021/pr300924j

MLA

Vancouver

Author

Fagerberg, Linn ; Oksvold, Per ; Skogs, Marie ; Algenas, Cajsa ; Lundberg, Emma ; Ponten, Fredrik ; Sivertsson, Asa ; Odeberg, Jacob ; Klevebring, Daniel ; Kampf, Caroline ; Asplund, Anna ; Sjostedt, Evelina ; Szigyarto, Cristina Al-Khalili ; Edqvist, Per-Henrik ; Olsson, IngMarie ; Rydberg, Urban ; Hudson, Paul ; Takanen, Jenny Ottosson ; Berling, Holger ; Bjorling, Lisa ; Tegel, Hanna ; Rockberg, Johan ; Nilsson, Peter ; Navani, Sanjay ; Jirström, Karin ; Mulder, Jan ; Schwenk, Jochen M. ; Zwahlen, Martin ; Hober, Sophia ; Forsberg, Mattias ; von Feilitzen, Kalle ; Uhlen, Mathias. / Contribution of Antibody-based Protein Profiling to the Human Chromosome-centric Proteome Project (C-HPP). In: Journal of Proteome Research. 2013 ; Vol. 12, No. 6. pp. 2439-2448.

RIS

TY - JOUR

T1 - Contribution of Antibody-based Protein Profiling to the Human Chromosome-centric Proteome Project (C-HPP)

AU - Fagerberg, Linn

AU - Oksvold, Per

AU - Skogs, Marie

AU - Algenas, Cajsa

AU - Lundberg, Emma

AU - Ponten, Fredrik

AU - Sivertsson, Asa

AU - Odeberg, Jacob

AU - Klevebring, Daniel

AU - Kampf, Caroline

AU - Asplund, Anna

AU - Sjostedt, Evelina

AU - Szigyarto, Cristina Al-Khalili

AU - Edqvist, Per-Henrik

AU - Olsson, IngMarie

AU - Rydberg, Urban

AU - Hudson, Paul

AU - Takanen, Jenny Ottosson

AU - Berling, Holger

AU - Bjorling, Lisa

AU - Tegel, Hanna

AU - Rockberg, Johan

AU - Nilsson, Peter

AU - Navani, Sanjay

AU - Jirström, Karin

AU - Mulder, Jan

AU - Schwenk, Jochen M.

AU - Zwahlen, Martin

AU - Hober, Sophia

AU - Forsberg, Mattias

AU - von Feilitzen, Kalle

AU - Uhlen, Mathias

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000)

PY - 2013

Y1 - 2013

N2 - A gene-centric Human Proteome Project has been proposed to characterize the human protein-coding genes in a chromosome-centered manner to understand human biology and disease. Here, we report on the protein evidence for all genes predicted from the genome sequence based on manual annotation from literature (UniProt), antibody-based profiling in cells, tissues and organs and analysis of the transcript profiles using next generation sequencing in human cell lines of different origins. We estimate that there is good evidence for protein existence for 69% (n = 13985) of the human protein-coding genes, while 23% have only evidence on the RNA level and 7% still lack experimental evidence. Analysis of the expression patterns shows few regards to protein evidence is visualized in a chromosome-centric manner as part of a new version of the Human Protein Atlas (www.proteinatlas.org).

AB - A gene-centric Human Proteome Project has been proposed to characterize the human protein-coding genes in a chromosome-centered manner to understand human biology and disease. Here, we report on the protein evidence for all genes predicted from the genome sequence based on manual annotation from literature (UniProt), antibody-based profiling in cells, tissues and organs and analysis of the transcript profiles using next generation sequencing in human cell lines of different origins. We estimate that there is good evidence for protein existence for 69% (n = 13985) of the human protein-coding genes, while 23% have only evidence on the RNA level and 7% still lack experimental evidence. Analysis of the expression patterns shows few regards to protein evidence is visualized in a chromosome-centric manner as part of a new version of the Human Protein Atlas (www.proteinatlas.org).

KW - Antibody-based protein profiling

KW - C-HPP

U2 - 10.1021/pr300924j

DO - 10.1021/pr300924j

M3 - Article

C2 - 23276153

VL - 12

SP - 2439

EP - 2448

JO - Journal of Proteome Research

JF - Journal of Proteome Research

SN - 1535-3893

IS - 6

ER -