Contribution of catalase to hydrogen peroxide resistance in Enterococcus faecalis.

Research output: Contribution to journalLetter

Abstract

Enterococcus faecalis exhibits high resistance to oxidative stress. Several enzymes are responsible for this trait. The role of alkyl hydroperoxide reductase (Ahp), thiol peroxidase (Tpx), and NADH peroxidase (Npr) in oxidative stress defense was recently characterized. Enterococcus faecalis, in contrast to many other streptococci, contains a catalase (KatA), but this enzyme can only be formed when the bacterium is supplied with heme. We have used this heme dependency of catalase activity and mutants deficient in KatA and Npr to investigate the role of the catalase in resistance against exogenous and endogenous hydrogen peroxide stress. The results demonstrate that in the presence of environmental heme catalase contributes to the protection against toxic effects of hydrogen peroxide.

Details

Authors
Organisations
External organisations
  • Lund University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Microbiology

Keywords

  • oxidative stress, heme, NADH peroxidase, streptococci
Original languageEnglish
Pages (from-to)160-164
JournalFEMS Microbiology Letters
Volume331
Issue number2
Publication statusPublished - 2012
Publication categoryResearch
Peer-reviewedNo