Controlled trial of a short and a prolonged course with ciprofloxacin in patients undergoing transurethral prostatic surgery

Research output: Contribution to journalArticle

Abstract

The efficacy of a short (Group I) and a prolonged (Group II) course with ciprofloxacin was assessed in patients undergoing transurethral prostatic resection for benign hyperplasia or cancer of the prostate and compared with that of controls without antibiotic (Group III). Both regiments significantly reduced the frequency of postoperative bacteriuria (p less than 0.01) and of severe infectious complications (p = 0.004) as compared to the controls. Both regimens were equally effective in preventing perioperative and postoperative acquisition of bacteriuria in patients without bacteriuria at surgery. In patients with bacteriuria before surgery, bacteriuria was found postoperatively in 35% in Group I and 10% in Group II (p = 0.012), but in 82% of the patients in Group III. Ciprofloxacin inhibited all but 7 of 176 bacterial strains at an MIC of less than or equal to 1 microgram/ml. Given orally ciprofloxacin is a valuable alternative antimicrobial for use in conjunction with transurethral prostatic resection. A short course is sufficient for prophylaxis, and adequate therapy is achieved with a prolonged regimen.

Details

Authors
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Microbiology in the medical area
  • Clinical Medicine
  • Urology and Nephrology
  • Cancer and Oncology
Original languageEnglish
Pages (from-to)11-17
JournalEuropean journal of clinical microbiology & infectious diseases
Volume6
Issue number1
Publication statusPublished - 1987
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Clinical Microbiology, Malmö (013011000), Pediatrics/Urology/Gynecology/Endocrinology (013240400), Division of Urological Cancers (013243420), Urology (013243400)