Convergent evolution of 11p allelic loss in multifocal Wilms tumors arising in WT1 mutation carriers

Research output: Contribution to journalArticle

Abstract

Wilms tumors in patients with constitutional WT1 mutations are examples of Knudson's tumor suppressor paradigm, with somatic inactivation of the second allele occurring through 11p loss of heterozygosity. The time point of this second hit has remained unknown. We analyzed seven Wilms tumors from two patients with constitutional WT1 mutations by whole exome sequencing and genomic array. All tumors exhibited wild type WT1 loss through uniparental isodisomy. Each tumor had a unique genomic breakpoint in 11p, typically accompanied by a private activating mutation of CTNNB1. Hence, convergent evolution rather than field carcinogenesis underlies multifocal tumors in WT1 mutation carriers.

Details

Authors
Organisations
External organisations
  • Karolinska University Hospital
  • Karolinska Institutet
  • Skåne University Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Medical Genetics
  • Cancer and Oncology

Keywords

  • convergent evolution, Denys–Drash syndrome, whole exome sequencing, Wilms tumor, WT1
Original languageEnglish
Article numbere27301
JournalPediatric Blood and Cancer
Volume65
Issue number11
Publication statusPublished - 2018 Nov 1
Publication categoryResearch
Peer-reviewedYes