Cord blood islet autoantibodies and seasonal association with the type 1 diabetes high-risk genotype.

Research output: Contribution to journalArticle

Abstract

Objective:Human leukocyte antigen DQ (HLA-DQ) genetic factors and islet autoantibodies are strongly associated with type 1 diabetes (T1D) and are currently used to predict T1D. This study examined whether islet autoantibodies in the cord blood of newborns to nondiabetic mothers were associated with the (T1D) high-risk genotype HLA-DQ2/8, gestational infections or both.Study Design:Cord blood samples were taken from 33 683 newborns and used for HLA typing and analyses of islet autoantibodies. Parents completed questionnaires when the child was 2 months of age.Result:The prevalence of newborn islet autoantibodies consistently varied with season over 4 years (P<0.0001); lowest in first quarter (1.2%) and highest in third (2.4%). Cord blood islet autoantibodies were associated with HLA-DQ2/8 in the second (OR, 2.30; P=0.02), third (OR, 2.12; P=0.008) and fourth quarters (OR, 2.49; P=0.007), but not in the first (OR, 1.13). Reported gastroenteritis was additionally associated with islet autoantibodies in the third quarter (OR, 1.80, P=0.04).Conclusion:An association between HLA and islet autoimmunity may depend on environmental exposure during pregnancy. Follow-up of mothers and children will determine risk of T1D.Journal of Perinatology (2008) 28, 211-217; doi:10.1038/sj.jp.7211912; published online 14 February 2008.

Details

Authors
  • Kristian Lynch
  • Barbro Lernmark
  • Juan Merlo
  • Maria Roberta Cilio
  • S-A Ivarsson
  • Åke Lernmark
  • Diabetes Prediction in Skåne (DiPiS) Study Group
Organisations
External organisations
  • Lund University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Environmental Health and Occupational Health
  • Endocrinology and Diabetes
Original languageEnglish
Pages (from-to)211-217
JournalJournal of Perinatology
Volume28
Issue number3
Publication statusPublished - 2008
Publication categoryResearch
Peer-reviewedYes

Related research output

Kristian Lynch, 2009, Social Epidemiology and Diabetes & Celiac Diseses, Dept of Clinical Scinces, Malmö. 144 p.

Research output: ThesisDoctoral Thesis (compilation)

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