Coronary flow and reactivity, but not arrhythmia vulnerability, are affected by cardioplegia during cardiopulmonary bypass surgery of piglets

Research output: Contribution to journalPublished meeting abstract

Abstract

Introduction: Cardiopulmonary bypass (CPB) surgery remains associated with significant cardiovascular morbidity in both pediatric and adult patients but the mechanisms are not fully clarified. Abnormalities in coronary flow and function have beensuggested to play an important role. A few prior studies suggested protective effects on coronary and myocardial function by short intravenous (i.v.) infusion of cyclosporine A prior to CPB surgery. Methods: Barrier-bred piglets (10-12 kg, n=20) were subjected to CPB with (n=10) or without (n=10) antegrade administration for 20 minutes of cardioplegic solution. Prior to surgery, half of animals from each group received 10-minute i.v. infusion of 100 mg/kg cyclosporine A. Left anterior descending coronary flow velocity responses to adenosine, serotonin, and atrial pacing, as well as left ventricular function and postsurgical vulnerability to atrial fibrillation (Afib) were assessed by intracoronary Doppler, epicardial echocardiography, and in vivo electrophysiological study, respectively. Results: Coronary peak flow velocity (cPFV) rose significantly after surgery, especially in cardioplegia group (p0.4). There was no difference in systolic myocardial function between groups at any timepoint. Conclusions: Cardioplegia during CPB surgery of piglets was associated with profound abnormalities in coronary vasomotor tone and receptor-related flow regulation, whereas arrhythmia vulnerability appeared to be comparable with that in non-cardioplegia group. In this study, intracoronary pretreatment with cyclosporine had no observable protective effect on coronary circulation or arrhythmia vulnerability after CPB surgery.

Details

Authors
  • P. Liuba
  • Sune Johansson
  • E. Pesonen
  • Thomas Higgins
  • A. Forslid
  • Axel Kornerup-Hansen
  • V. Perez De Sa
Organisations
External organisations
  • Skåne University Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cardiac and Cardiovascular Systems

Keywords

  • cyclosporin, serotonin, adenosine, cyclosporin A, receptor, cardioplegic agent, cardioplegia, bypass surgery, Japanese (people), coronary artery blood flow, cardiopulmonary bypass, heart arrhythmia, society, piglet, cardiology, heart surgery, pediatric cardiology, surgery, flow rate, heart atrium pacing, heart function, infusion, morbidity, heart left ventricle function, atrial fibrillation, adult, patient, peak expiratory flow, echocardiography, intravenous drug administration
Original languageEnglish
Article numberP-47
Pages (from-to)S70
JournalCardiology in the Young
Volume21
Issue numberS1
Publication statusPublished - 2011 May 1
Publication categoryResearch
Peer-reviewedYes
Event45th Annual Meeting of the European Paediatric Cardiology - Granada, Spain
Duration: 2011 May 182011 May 21
Conference number: 45