Coronary heart disease mortality after 5 years of adjuvant tamoxifen therapy: Results from a randomized trial

Research output: Contribution to journalArticle

Abstract

From January 1, 1983, through December 31, 1992, a total of 4610 patients entered a randomized trial that compared mortality among patients receiving 2 years of adjuvant tamoxifen therapy with that in patients receiving 5 years of adjuvant tamoxifen therapy, 4175 of whom were recurrence free after 2 years of tamoxifen therapy. Among the 2046 patients randomly assigned to the 5-year group all-cause mortality, breast cancer-specific mortality, and the incidence of contralateral breast cancer were reduced, compared with those among 2129 patients randomized in the 2-year group, but the incidence of endometrial cancer was increased. In addition, mortality from coronary heart disease was statistically significantly reduced in the 5-year group, compared with that in the 2-year group (hazard ratio = 0.67, 95% confidence interval = 0.47 to 0.94; P = .022 [two-sided Wald test]). Ten years after surgery, 2.1% of the patients in the 5-year group and 3.5% of those in the 2-year group a died from coronary heart disease. No statistically significant increases in mortality from other heart diseases, cerebrovascular diseases, or other vascular diseases were observed.

Details

Authors
  • B Nordenskjold
  • J Rosell
  • L E Rutqvist
  • Per Malmström
  • J Bergh
  • N O Bengtsson
  • T Hatschek
  • A Wallgren
  • J Carstensen
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology
Original languageEnglish
Pages (from-to)1609-1610
JournalJournal of the National Cancer Institute
Volume97
Issue number21
Publication statusPublished - 2005
Publication categoryResearch
Peer-reviewedYes